Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Helmholtz Institute for RNA-based Infection Research (HIRI), Würzburg, Germany.
EMBO J. 2018 Jul 2;37(13). doi: 10.15252/embj.201899875. Epub 2018 Jun 22.
Long non‐coding RNAs (lncRNAs) play important roles in many cellular pathways, but their contribution to the defense of eukaryotic cells against pathogens remains poorly understood. A new study from Imamura in reports that infection in human cells impacts nuclear RNA decay, which in turn drives the accumulation of otherwise unstable nuclear lncRNAs, some of which may have protective effects against this common bacterial pathogen. These unexpected findings demand more efforts to fully decrypt the molecular functions of lncRNAs in innate and adaptive immunity.
长非编码 RNA（lncRNA）在许多细胞途径中发挥着重要作用，但它们对真核细胞抵御病原体的防御作用仍知之甚少。Imamura 在 发表的一项新研究报告称， 感染人类细胞会影响核 RNA 的降解，进而导致原本不稳定的核 lncRNA 积累，其中一些 lncRNA 可能对这种常见的细菌病原体具有保护作用。这些出人意料的发现需要我们付出更多努力，以充分揭示 lncRNA 在先天免疫和适应性免疫中的分子功能。
