Zur Bruegge Jennifer, Einspanier Ralf, Sharbati Soroush
Department of Veterinary Medicine, Institute of Veterinary Biochemistry, Freie Universität Berlin Berlin, Germany.
Front Cell Infect Microbiol. 2017 Mar 28;7:95. doi: 10.3389/fcimb.2017.00095. eCollection 2017.
Bacterial pathogens have coevolved with their hosts and acquired strategies to circumvent defense mechanisms of host cells. It was shown that bacteria interfere with the expression of mammalian microRNAs to modify immune signaling, autophagy, or the apoptotic machinery. Recently, a new class of regulatory RNAs, long non-coding RNAs (lncRNAs), was reported to have a pivotal role in the regulation of eukaryotic gene expression. A growing body of literature reports on specific involvement of lncRNAs in the host cell response toward bacterial infections. This mini review summarizes recent data that focuses on lncRNA function in host cells during bacterial infection and provides a perspective where future research in this regard may be going.
细菌病原体与其宿主共同进化，并获得了规避宿主细胞防御机制的策略。研究表明，细菌会干扰哺乳动物微小RNA的表达，以改变免疫信号传导、自噬或凋亡机制。最近，一类新的调控RNA，即长链非编码RNA（lncRNA），据报道在真核基因表达调控中起关键作用。越来越多的文献报道了lncRNA在宿主细胞对细菌感染的反应中的具体作用。这篇小型综述总结了最近聚焦于lncRNA在细菌感染期间宿主细胞功能的数据，并提供了这方面未来研究可能的方向。
