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1
Restriction fragment length polymorphism of the gene encoding the alpha chain of the human T cell receptor.人类T细胞受体α链编码基因的限制性片段长度多态性
J Exp Med. 1985 Sep 1;162(3):1087-92. doi: 10.1084/jem.162.3.1087.
2
Polymorphism in human T cell receptor alpha chain variable region genes.人类T细胞受体α链可变区基因的多态性
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3
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4
Molecular determination of T-cell receptor alpha and beta chain genotypes in human families.人类家族中T细胞受体α和β链基因型的分子测定
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5
Restriction fragment length polymorphism of the human T cell receptor alpha gene. I. Two polymorphic restriction sites localized to different regions of the gene.
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6
Molecular genotypes of the human T cell receptor gamma-chain.
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The T-cell receptor alpha, beta and gamma polymorphism in Japanese.日本人T细胞受体α、β和γ的多态性
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Polymorphic Bgl II restriction sites of DR alpha demarcate a novel HLA-DR1 antigen.DRα的多态性Bgl II限制性位点界定了一种新型HLA - DR1抗原。
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Genetic recombination within the human T-cell receptor alpha-chain gene complex.人类T细胞受体α链基因复合体内的基因重组。
Proc Natl Acad Sci U S A. 1987 Dec;84(24):9089-93. doi: 10.1073/pnas.84.24.9089.
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引用本文的文献

1
Splenic CD4+ T Cells in Progressive Visceral Leishmaniasis Show a Mixed Effector-Regulatory Phenotype and Impair Macrophage Effector Function through Inhibitory Receptor Expression.进行性内脏利什曼病中脾脏CD4+ T细胞表现出混合效应-调节表型，并通过抑制性受体表达损害巨噬细胞效应功能。
PLoS One. 2017 Jan 19;12(1):e0169496. doi: 10.1371/journal.pone.0169496. eCollection 2017.
2
Molecular genetics of murine lupus.小鼠狼疮的分子遗传学
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Inherited polymorphism of the human T-cell antigen receptor detected by a monoclonal antibody.通过单克隆抗体检测到的人类T细胞抗原受体的遗传多态性。
Proc Natl Acad Sci U S A. 1986 Oct;83(20):7888-92. doi: 10.1073/pnas.83.20.7888.
4
T-cell clones and T-cell receptors.T细胞克隆与T细胞受体。
Microbiol Rev. 1986 Mar;50(1):50-69. doi: 10.1128/mr.50.1.50-69.1986.
5
Delineation of a defect in T cell receptor beta genes of NZW mice predisposed to autoimmunity.易患自身免疫性疾病的新西兰小鼠T细胞受体β基因缺陷的描绘。
J Exp Med. 1986 Mar 1;163(3):644-53. doi: 10.1084/jem.163.3.644.
6
Genetic recombination within the human T-cell receptor alpha-chain gene complex.人类T细胞受体α链基因复合体内的基因重组。
Proc Natl Acad Sci U S A. 1987 Dec;84(24):9089-93. doi: 10.1073/pnas.84.24.9089.
7
Restriction fragment length polymorphism of the human T cell receptor alpha gene. I. Two polymorphic restriction sites localized to different regions of the gene.
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8
Molecular aspects of murine systemic lupus erythematosus.小鼠系统性红斑狼疮的分子层面
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Detection and mapping of polymorphic KpnI alleles in the human T-cell receptor constant beta-2 locus.人类T细胞受体恒定β-2基因座中多态性KpnI等位基因的检测与定位
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T cell receptor genes in rheumatoid arthritis.类风湿关节炎中的T细胞受体基因。
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本文引用的文献

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The major histocompatibility complex-restricted antigen receptor on T cells. I. Isolation with a monoclonal antibody.T细胞上主要组织相容性复合体限制的抗原受体。I. 用单克隆抗体进行分离。
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A human T cell-specific cDNA clone encodes a protein having extensive homology to immunoglobulin chains.一个人类T细胞特异性cDNA克隆编码一种与免疫球蛋白链具有广泛同源性的蛋白质。
Nature. 1984;308(5955):145-9. doi: 10.1038/308145a0.
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Isolation of cDNA clones encoding T cell-specific membrane-associated proteins.编码T细胞特异性膜相关蛋白的cDNA克隆的分离
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Clonotypic structures involved in antigen-specific human T cell function. Relationship to the T3 molecular complex.参与抗原特异性人类T细胞功能的克隆型结构。与T3分子复合物的关系。
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Gene for alpha-chain of human T-cell receptor: location on chromosome 14 region involved in T-cell neoplasms.人类T细胞受体α链基因：位于14号染色体上与T细胞肿瘤相关的区域。
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10
Analysis of cDNA clones specific for human T cells and the alpha and beta chains of the T-cell receptor heterodimer from a human T-cell line.对来自人T细胞系的人T细胞特异性cDNA克隆以及T细胞受体异二聚体的α和β链的分析。
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人类T细胞受体α链编码基因的限制性片段长度多态性

Restriction fragment length polymorphism of the gene encoding the alpha chain of the human T cell receptor.

作者信息

Hoover M L, Marks J, Chipman J, Palmer E, Stastny P, Capra J D

出版信息

J Exp Med. 1985 Sep 1;162(3):1087-92. doi: 10.1084/jem.162.3.1087.

DOI:10.1084/jem.162.3.1087
PMID:2993469
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2187817/
Abstract

Two allelic forms of the T cell antigen receptor alpha chain gene were discerned by restriction fragment length polymorphism (RFLP) employing the T cell antigen receptor alpha chain probe pGA5, and the restriction enzyme Bgl II. Analysis revealed that the polymorphic fragments are detected by a probe specific for the constant region exon of the T cell antigen receptor alpha chain gene. Furthermore, the polymorphic fragments were shown to segregate within families. The two allelic forms yield two homozygous states, 3.2/3.2 and 2.9/2.9, at a frequency of 76.5 and 2.9%, respectively, within the normal population. The heterozygous state was observed in 20.6% of the population. The discovery of allelic forms of both the alpha and beta chains of the T cell antigen receptor genes may provide a unique opportunity to study heritable markers of T cell function in several human diseases.

摘要

利用T细胞抗原受体α链探针pGA5和限制性内切酶Bgl II，通过限制性片段长度多态性（RFLP）识别出T细胞抗原受体α链基因的两种等位基因形式。分析表明，多态性片段可被T细胞抗原受体α链基因恒定区外显子特异性探针检测到。此外，多态性片段在家族中呈分离状态。在正常人群中，这两种等位基因形式分别产生两种纯合状态，即3.2/3.2和2.9/2.9，频率分别为76.5%和2.9%。在20.6%的人群中观察到杂合状态。T细胞抗原受体基因α链和β链等位基因形式的发现可能为研究几种人类疾病中T细胞功能的遗传标记提供独特的机会。