Departamento de Química Analítica y Análisis Instrumental, Facultad de Ciencias, c/Francisco Tomás y Valiente, N°7, Campus de Excelencia de la Universidad Autónoma de Madrid, 28049, Madrid, Spain.
ESISNA group, Materials Science Factory, Instituto de Ciencia de Materiales de Madrid (ICMM). Consejo Superior de Investigaciones Científicas (CSIC), Sor Juana Inés de la Cruz 3, 28049, Madrid, Spain.
Mikrochim Acta. 2018 Jun 22;185(7):334. doi: 10.1007/s00604-018-2793-7.
The authors describe an electrochemical sensor based on the use of diamond nanoparticles (DNPs) and molybdenum disulfide (MoS) platelets. The sensor was applied to the voltammetric determination of the anticonvulsant valproic acid which was previously derivatized with ferrocene. The MoS platelets were obtained by an exfoliation method, and the DNPs were directly dispersed in water and subsequently deposited on a glassy carbon electrode (GCE). The sensor response was optimized in terms of the solvent employed for dispersing the MoS nanomaterial and the method for modifying the GCE. Sensors consisting of a first layer of MoS dispersed in ethanol/water and a second layer of DNPs give better response. The single steps of sensor construction were characterized by atomic force microscopy and electrochemical impedance spectroscopy. The differential pulse voltammetric response of the GCE (measured at +0.18 V vs. Ag/AgCl) was compared to that of sensors incorporating only one of the nanomateriales (DNPs or MoS). The formation of a hybrid MoS-DNP structure clearly improves performance. The GCE containing both nanomaterials exhibits high sensitivity (740 µA ⋅ mM ⋅ cm), a 0.27 μM detection limit, and an 8% reproducibility (RSD). The sensor retained 99% of its initial response after 45 days of storage. Graphical abstract Electrochemical sensor by co-immobilization of MoS and diamond nanoparticles (DNP). The formation of a hybrid MoS-DNP structure enhances the performance of the sensor towards valproic acid derivatized with a ferrocene group, when compared with sensors incorporating only DNP or MoS.
作者描述了一种基于使用金刚石纳米粒子（DNP）和二硫化钼（MoS）片的电化学传感器。该传感器应用于伏安法测定先前用二茂铁衍生的抗惊厥药丙戊酸。MoS 片通过剥离方法获得，DNP 直接分散在水中，随后沉积在玻碳电极（GCE）上。根据用于分散 MoS 纳米材料的溶剂和修饰 GCE 的方法优化了传感器的响应。由第一层分散在乙醇/水中的 MoS 和第二层 DNP 组成的传感器具有更好的响应。通过原子力显微镜和电化学阻抗谱对传感器的构建的单个步骤进行了表征。与仅包含一种纳米材料（DNP 或 MoS）的传感器相比，测量在+0.18 V 相对于 Ag/AgCl 处的 GCE 的差分脉冲伏安响应。形成混合 MoS-DNP 结构可明显改善性能。含有两种纳米材料的 GCE 表现出高灵敏度（740 µA ⋅ mM ⋅ cm）、0.27 μM 的检测限和 8%的重现性（RSD）。传感器在储存 45 天后仍保留 99%的初始响应。电化学传感器通过共固定 MoS 和金刚石纳米粒子（DNP）。与仅包含 DNP 或 MoS 的传感器相比，形成混合 MoS-DNP 结构可增强传感器对用二茂铁基团衍生的丙戊酸的性能。
