Molecular Parasitology Laboratory, Molecular Biology and Genetics Unit, Jawaharlal Nehru Centre for Advanced Scientific Research, Jakkur, Bangalore, India.
W. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD.
IUBMB Life. 2018 Aug;70(8):732-742. doi: 10.1002/iub.1878. Epub 2018 Jun 22.
The complex life cycle of intracellular parasitic protozoans entails multiple rounds of DNA replication and mitosis followed by cytokinesis to release daughter parasites. To gain insights into mitotic events it is imperative to identify the biomarkers that constitute the chromosome segregation machinery in the parasite. Chromosomal loci called centromeres and their associated proteins play an essential role in accurate chromosome segregation. Although new information on the centromere-kinetochore proteins has been added to the existing pool of knowledge, a paucity of biomarkers for nuclear division prevents a global view of chromosome segregation mechanism in the malaria parasite. In Plasmodium falciparum, except CENH3 and CENP-C homologues, other centromere associated proteins responsible for centromere functions and kinetochore assembly are not known. The focus of this review is to summarize the current understanding on the centromere organization and its associated proteins in eukaryotes with the emerging information in P. falciparum. © 2018 IUBMB Life, 70(8):732-742, 2018.
内寄生原生动物的复杂生命周期需要多次 DNA 复制和有丝分裂，然后进行胞质分裂以释放子虫体。为了深入了解有丝分裂事件，必须确定构成寄生虫染色体分离机制的生物标志物。称为着丝粒的染色体位点及其相关蛋白在准确的染色体分离中起着至关重要的作用。尽管关于着丝粒-动粒蛋白的新知识已经添加到现有的知识库中，但核分裂的生物标志物匮乏，阻止了人们对疟原虫染色体分离机制的全面了解。在恶性疟原虫中，除了 CENH3 和 CENP-C 同源物外，其他负责着丝粒功能和动粒组装的着丝粒相关蛋白尚不清楚。本篇综述的重点是总结真核生物中着丝粒组织及其相关蛋白的现有认识，并结合恶性疟原虫中的新兴信息。 © 2018 IUBMB Life, 70(8):732-742, 2018.
