成人难治性与良好控制癫痫患者细胞因子和氧化应激标志物的比较：一项横断面研究。
Comparison of cytokines and prooxidants/antioxidants markers among adults with refractory versus well-controlled epilepsy: A cross-sectional study.
机构信息
Harran University School of Medicine, Department of Neurology, Şanlıurfa, Turkey.
Harran University School of Medicine, Department of Neurology, Şanlıurfa, Turkey.
出版信息
Seizure. 2018 Aug;60:105-109. doi: 10.1016/j.seizure.2018.06.009. Epub 2018 Jun 15.
PURPOSE
This study aims to investigate the serum adiponectin, interleukin (IL)-6 and oxidative stress in epilepsy patients who are refractory or non-refractory to treatments.
METHOD
The study comprised 31 refractory epilepsy, 29 well-controlled epilepsy patients and control group including 29 healthy individuals. The serum adiponectin, IL-6, total antioxidant status (TAS), total oxidant status levels (TOS) and oxidative stress index (OSİ) were determined.
RESULTS
The mean serum adiponectin and TAS levels were significantly lower in the refractory epilepsy patients than in the healty controls, and mean IL-6, TOS and OSİ levels were significantly higher. The serum adiponectin, IL-6, TAS, TOS and OSI levels were not significantly different between the well-controlled epilepsy patients and the healthy controls.
CONCLUSIONS
The mean serum IL-6 and oxidative stress levels in refractory epilepsy patients were higher and the serum adiponectin level was lower than the healthy control group. These findings may be associated with an increased risk of seizures, atherosclerosis and cardiovascular disease in refractory epilepsy patients.
目的
本研究旨在探讨治疗抵抗或无反应的癫痫患者的血清脂联素、白细胞介素（IL）-6 和氧化应激情况。
方法
研究纳入 31 例治疗抵抗性癫痫患者、29 例病情控制良好的癫痫患者和 29 例健康对照组。测定血清脂联素、IL-6、总抗氧化状态（TAS）、总氧化状态水平（TOS）和氧化应激指数（OSİ）。
结果
治疗抵抗性癫痫患者的血清脂联素和 TAS 水平明显低于健康对照组，而血清 IL-6、TOS 和 OSİ 水平明显升高。病情控制良好的癫痫患者的血清脂联素、IL-6、TAS、TOS 和 OSİ 水平与健康对照组无显著差异。
结论
治疗抵抗性癫痫患者的血清 IL-6 和氧化应激水平较高，脂联素水平较低，这可能与治疗抵抗性癫痫患者癫痫发作、动脉粥样硬化和心血管疾病风险增加有关。
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