Critical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, MD.
Cancer Therapy Evaluation Program, Division of Cancer Treatment & Diagnosis, National Cancer Institute, National Institutes of Health, Bethesda, MD.
Semin Oncol. 2017 Dec;44(6):428-432. doi: 10.1053/j.seminoncol.2017.12.001. Epub 2018 Jan 6.
Disruption of liver immune tolerance allows for the development of autoimmune hepatitis (AIH) and hepatocellular carcinoma (HCC). AIH rarely progresses to HCC but the diseases similarly induce the production of IL-18 and matrix metalloproteinases. These molecules have distinct effects on the immune response, including the programmed cell-death 1 (PD-1) axis. In this review, differences in PD-1 function and possible cell signals in AIH and HCC are highlighted.
肝免疫耐受的破坏可导致自身免疫性肝炎（AIH）和肝细胞癌（HCC）的发生。AIH 很少进展为 HCC，但这两种疾病同样会诱导白细胞介素 18 和基质金属蛋白酶的产生。这些分子对免疫反应有不同的影响，包括程序性细胞死亡 1（PD-1）轴。在这篇综述中，强调了 AIH 和 HCC 中 PD-1 功能和可能的细胞信号的差异。
