Neuropsychiatric Epidemiology Unit, Section for Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Mölndal, Sweden.
Neuropsychiatric Epidemiology Unit, Section for Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Mölndal, Sweden.
Alzheimers Dement. 2018 Oct;14(10):1253-1260. doi: 10.1016/j.jalz.2018.05.009. Epub 2018 Jun 21.
Longitudinal studies are needed to understand the long-term associations between stroke and dementia.
A population sample of 1460 women without stroke or dementia at baseline was followed over 44 years, from 1968 to 2012. Information on stroke and dementia was obtained from neuropsychiatric examinations, key-informant interviews, hospital registry, and medical records.
During 44 years follow-up, 362 women developed stroke and 325, dementia. The age-specific incidence of the two disorders was similar. The incidence of dementia was higher in those with stroke than among those without (33.7% vs. 18.5%; age-adjusted hazard ratio 1.44, 95% confidence interval 1.15-1.81). The increased risk of dementia started already 5 years before stroke, was highest 1 year after stroke, and continued more than 11 years after stroke.
There is an increased risk for dementia both before and after stroke. This has implications for understanding the relation between the two disorders and for prevention of dementia and stroke.
需要进行纵向研究，以了解中风和痴呆之间的长期关联。
本研究为一项人群样本研究，共纳入了 1460 名基线时无中风或痴呆的女性，随访时间长达 44 年（1968 年至 2012 年）。中风和痴呆的信息通过神经精神检查、关键知情人访谈、医院登记和医疗记录获取。
在 44 年的随访期间，有 362 名女性发生了中风，325 名女性发生了痴呆。两种疾病的特定年龄发病率相似。发生中风的女性发生痴呆的风险高于未发生中风的女性（33.7%比 18.5%；年龄调整后的风险比 1.44，95%置信区间 1.15-1.81）。发生痴呆的风险在中风前 5 年就开始增加，在中风后 1 年达到最高，并且在中风后 11 年以上仍持续存在。
中风前后发生痴呆的风险均增加。这对理解两种疾病之间的关系以及预防痴呆和中风具有重要意义。
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