Donders Institute for Brain, Cognition and Behaviour, Radboud University, P.O. Box. 9101, Nijmegen, 6500 HB, The Netherlands; Max Planck Institute for Psycholinguistics, P.O. Box 310, Nijmegen, 6500 AH, The Netherlands.
Donders Institute for Brain, Cognition and Behaviour, Radboud University, P.O. Box. 9101, Nijmegen, 6500 HB, The Netherlands.
Neuroimage. 2018 Oct 1;179:326-336. doi: 10.1016/j.neuroimage.2018.06.061. Epub 2018 Jun 21.
Speaking is a complex motor skill which requires near instantaneous integration of sensory and motor-related information. Current theory hypothesizes a complex interplay between motor and auditory processes during speech production, involving the online comparison of the speech output with an internally generated forward model. To examine the neural correlates of this intricate interplay between sensory and motor processes, the current study uses altered auditory feedback (AAF) in combination with magnetoencephalography (MEG). Participants vocalized the vowel/e/and heard auditory feedback that was temporarily pitch-shifted by only 25 cents, while neural activity was recorded with MEG. As a control condition, participants also heard the recordings of the same auditory feedback that they heard in the first half of the experiment, now without vocalizing. The participants were not aware of any perturbation of the auditory feedback. We found auditory cortical areas responded more strongly to the pitch shifts during vocalization. In addition, auditory feedback perturbation resulted in spectral power increases in the θ and lower β bands, predominantly in sensorimotor areas. These results are in line with current models of speech production, suggesting auditory cortical areas are involved in an active comparison between a forward model's prediction and the actual sensory input. Subsequently, these areas interact with motor areas to generate a motor response. Furthermore, the results suggest that θ and β power increases support auditory-motor interaction, motor error detection and/or sensory prediction processing.
说话是一种复杂的运动技能，需要即时整合感觉和运动相关信息。目前的理论假设在言语产生过程中运动和听觉过程之间存在复杂的相互作用，涉及在线比较言语输出与内部产生的前向模型。为了研究感觉和运动过程之间这种复杂相互作用的神经相关性，当前的研究使用改变的听觉反馈 (AAF) 结合脑磁图 (MEG)。参与者发声元音 /e/，并听到听觉反馈，该反馈暂时仅被音高移动 25 美分，而 MEG 则记录神经活动。作为对照条件，参与者还听到了他们在前半部分实验中听到的相同听觉反馈的录音，但现在不发声。参与者不知道听觉反馈有任何干扰。我们发现，在发声时听觉皮层区域对音高移动的反应更强烈。此外，听觉反馈的干扰导致 θ 和较低的 β 频段的频谱功率增加，主要在感觉运动区域。这些结果与当前的言语产生模型一致，表明听觉皮层区域参与了前向模型的预测与实际感觉输入之间的主动比较。随后，这些区域与运动区域相互作用以产生运动反应。此外，结果表明 θ 和 β 功率增加支持听觉-运动相互作用、运动误差检测和/或感觉预测处理。
