Institut für Zellbiologie und Neurowissenschaft, Goethe-Universität, 60438, Frankfurt/M, Germany.
Ernst Strüngmann Institute (ESI) for Neuroscience in Cooperation with Max Planck Society, 60528, Frankfurt am Main, Germany.
Nat Commun. 2022 Jun 25;13(1):3642. doi: 10.1038/s41467-022-31230-6.
The mammalian frontal and auditory cortices are important for vocal behavior. Here, using local-field potential recordings, we demonstrate that the timing and spatial patterns of oscillations in the fronto-auditory network of vocalizing bats (Carollia perspicillata) predict the purpose of vocalization: echolocation or communication. Transfer entropy analyses revealed predominant top-down (frontal-to-auditory cortex) information flow during spontaneous activity and pre-vocal periods. The dynamics of information flow depend on the behavioral role of the vocalization and on the timing relative to vocal onset. We observed the emergence of predominant bottom-up (auditory-to-frontal) information transfer during the post-vocal period specific to echolocation pulse emission, leading to self-directed acoustic feedback. Electrical stimulation of frontal areas selectively enhanced responses to sounds in auditory cortex. These results reveal unique changes in information flow across sensory and frontal cortices, potentially driven by the purpose of the vocalization in a highly vocal mammalian model.
哺乳动物的额叶和听觉皮层对发声行为很重要。在这里，我们使用局部场电位记录，证明了发声蝙蝠（Carollia perspicillata）的额听觉网络中振荡的时间和空间模式可以预测发声的目的：回声定位或通讯。传递熵分析显示，在自发活动和发声前期间，主要是自上而下（额叶到听觉皮层）的信息流。信息流的动态取决于发声的行为作用以及与发声开始的时间关系。我们观察到，在回声定位脉冲发射特有的发声后期间，主要是自下而上（听觉到额叶）的信息传递出现，导致自我导向的声音反馈。额叶区域的电刺激选择性地增强了对听觉皮层声音的反应。这些结果揭示了信息流在感觉和额叶皮层之间的独特变化，这可能是由高度发声的哺乳动物模型中发声的目的驱动的。
