透皮芬太尼溶液对雄性大鼠后爪切口术后疼痛模型具有长期镇痛作用。
Transdermal Fentanyl Solution Provides Long-term Analgesia in the Hind-paw Incisional Model of Postoperative Pain in Male Rats.
作者信息
Clemensen Johanne, Rasmussen Lena V, Abelson Klas S P
机构信息
Department of Experimental Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Department of Experimental Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
出版信息
In Vivo. 2018 Jul-Aug;32(4):713-719. doi: 10.21873/invivo.11299.
BACKGROUND
A recently developed transdermal fentanyl solution was hypothesized to be effective for non-invasive postoperative analgesia in rats.
MATERIALS AND METHODS
Thirty-nine male Sprague-Dawley rats were treated once with 0.1, 0.33 or 1.0 mg/kg transdermal fentanyl solution at the skin of the scruff 1 h prior to subjected to hind-paw surgery, and compared to non-treated animals. All rats were tested for nociceptive response in the electronic von Frey (EVF) test between 1 and 72 h postoperatively, and assessed daily with regards to facial expression, body weight changes and welfare score.
RESULTS
Fentanyl treatment at all doses significantly reduced nociceptive response in the EVF test throughout the 72 h of experimentation, reduced facial expressions on all days postoperatively, slightly reduced the body weight and improved postoperative welfare parameters.
CONCLUSION
The present study indicates that transdermal fentanyl solution seems to be an effective, non-invasive and long-lasting analgesic regimen in male rats.
背景
一种最近研发的透皮芬太尼溶液被假定对大鼠术后非侵入性镇痛有效。
材料与方法
39只雄性Sprague-Dawley大鼠在进行后爪手术前1小时，于颈部皮肤处给予0.1、0.33或1.0mg/kg的透皮芬太尼溶液进行单次治疗，并与未治疗的动物进行比较。所有大鼠在术后1至72小时内进行电子von Frey（EVF）试验以检测伤害性反应，并每天对面部表情、体重变化和福利评分进行评估。
结果
在整个72小时的实验过程中，所有剂量的芬太尼治疗均显著降低了EVF试验中的伤害性反应，术后所有天数的面部表情均有所减少，体重略有下降，术后福利参数得到改善。
结论
本研究表明，透皮芬太尼溶液似乎是雄性大鼠一种有效、非侵入性且持久的镇痛方案。
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