Department of Experimental Medicine, University of Copenhagen, Copenhagen, Denmark.
Lab Anim. 2012 Oct;46(4):349-51. doi: 10.1258/la.2012.012028. Epub 2012 Sep 11.
An adequate analgesic strategy is important to improve the postoperative recovery and welfare of laboratory rats and mice. It is desirable that the method for administering the drug is non-invasive and stress-free. We have previously validated a method for administering buprenorphine in a nut paste for voluntary ingestion. This method has many advantages over parenteral administration. To use the method in a successful way, however, it is important to prepare and administer the mix correctly. The present paper describes in detail how to implement the method, by means of habituation, presentation, adequate concentrations and amounts of buprenorphine/nut paste, and dosage of buprenorphine to rats and mice.
制定充分的镇痛策略对改善实验大鼠和小鼠的术后恢复和福利非常重要。理想的给药方法应是非侵入性且无应激的。我们先前已经验证了将丁丙诺啡掺入坚果糊中供动物自愿摄入的给药方法。与注射相比，该方法具有许多优势。然而，要成功使用该方法，正确准备和给药非常重要。本文详细介绍了如何通过适应、呈现、适当的丁丙诺啡/坚果糊浓度和剂量以及给大鼠和小鼠的丁丙诺啡剂量来实施该方法。
