Taylor B A, Rowe L, Jenkins N A, Copeland N G
J Virol. 1985 Oct;56(1):172-5. doi: 10.1128/JVI.56.1.172-175.1985.
The AKR/J mouse strain is genetically fixed for three different ecotropic murine leukemia virus genomes, designated Akv-1, Akv-3, and Akv-4 (Emv-11, Emv-13, and Emv-14). With recombinant inbred strains and crosses with linkage-testing stocks, Akv-3 and Akv-4 were placed on the mouse chromosome map. Akv-3, which encodes a replication-defective provirus, maps near the agouti coat color locus, a, on chromosome 2. Akv-4, which is replication competent, maps near the neurological mutant gene locus trembler, Tr, on chromosome 11. Akv-1 and Akv-2 (Emv-12), an ecotropic provirus carried by AKR/N but not AKR/J, have previously been mapped to chromosome 7 and 16, respectively. Thus, the four Akv proviruses mapped to date are on four different chromosomes. Akv-3 is the second ecotropic murine leukemia virus provirus to be mapped near the agouti locus. The results are discussed in relation to possible nonrandomness of viral integration.
AKR/J小鼠品系在基因上固定有三种不同的嗜亲性鼠白血病病毒基因组，分别命名为Akv-1、Akv-3和Akv-4（Emv-11、Emv-13和Emv-14）。通过重组近交系以及与连锁测试品系的杂交，将Akv-3和Akv-4定位到了小鼠染色体图谱上。编码复制缺陷型原病毒的Akv-3定位于2号染色体上的刺鼠毛色基因座a附近。具有复制能力的Akv-4定位于11号染色体上的神经学突变基因座颤抖（trembler，Tr）附近。Akv-1和Akv-2（Emv-12），一种由AKR/N而非AKR/J携带的嗜亲性原病毒，此前已分别定位到7号和16号染色体上。因此，迄今定位的四种Akv原病毒位于四条不同的染色体上。Akv-3是第二种定位在刺鼠基因座附近的嗜亲性鼠白血病病毒原病毒。结合病毒整合可能的非随机性对结果进行了讨论。
