Yu J, Zhang T, Wang Y, Gao J M, Hua J, Tian J M, Ding Y F, Zhang J, Chen L L, Li J Q, Zhao G M
School of Public Health, Fudan University, Shanghai 200032, China.
Soochow University Affiliated Children's Hospital, Suzhou 215003, China.
Zhonghua Liu Xing Bing Xue Za Zhi. 2018 Jun 10;39(6):847-851. doi: 10.3760/cma.j.issn.0254-6450.2018.06.029.
To understand the clinical characteristics and economic burden of influenza-like illness (ILI) children aged 0-59 months in the outpatient settings in Suzhou, China, 2011-2017. From March 2011 to February 2017, we conducted a prospective surveillance program on ILI for children aged less than 5 years at Soochow University Affiliated Children's Hospital. Through standard questionnaires and follow-up survey via telephone, we collected information regarding the demographic characteristics, medical history, clinical symptoms and both direct and indirect costs associated with influenza, of the patients. We then compared clinical characteristics and economic burden of influenza A/H1N1, A/H3N2, and B infections among children with ILI. We enrolled 6 310 patients with ILI from March 2011 to February 2017 and collected all their throat swabs. 791 (12.9) of the swabs showed positive for influenza virus, including 88 (11.1) subtype influenza A/H1N1, 288 (36.4) subtype influenza A/H3N2, and 415(52.5) type influenza B. The proportions of cough, rhinorrhea, wheezing, vomiting and convulsion in influenza-positive children were higher than those influenza-negative children. Except for the prevalence rates of cough ((2)=9.227, =0.010), wheezing ((2)=7.273, =0.026) and vomiting ((2)=8.163, =0.017), other clinical symptoms appeared similar between the three viral subtypes. Among all the ILI children, the average total cost per episode of influenza was 688.4 Yuan (95: 630.1-746.7) for influenza-negative children; 768.0 Yuan (95: 686.8-849.3) for influenza-positive children and 738.3 Yuan (95: 655.5-821.1) for influenza B. Children with influenza A/H1N1 spent much more than those with influenza A/H3N2 or influenza B in the total cost ((2)=7.237, =0.028). Children infected influenza showed higher prevalence rates of cough, rhinorrhea, wheezing, vomiting and convulsion than those without influenza. Influenza A/H1N1 subtype caused heavier economic burden than the other two influenza subtypes.
为了解2011 - 2017年中国苏州门诊环境中0 - 59个月龄流感样疾病（ILI）儿童的临床特征和经济负担。2011年3月至2017年2月，我们在苏州大学附属儿童医院对5岁以下儿童的ILI开展了一项前瞻性监测项目。通过标准问卷和电话随访调查，我们收集了患者的人口统计学特征、病史、临床症状以及与流感相关的直接和间接费用信息。然后，我们比较了ILI儿童中甲型H1N1流感、甲型H3N2流感和乙型流感感染的临床特征和经济负担。2011年3月至2017年2月，我们纳入了6310例ILI患者，并收集了他们所有的咽拭子。791份（12.9%）咽拭子流感病毒检测呈阳性，其中甲型H1N1流感亚型88份（11.1%），甲型H3N2流感亚型288份（36.4%），乙型流感415份（52.5%）。流感阳性儿童咳嗽、流涕、喘息、呕吐和惊厥的比例高于流感阴性儿童。除咳嗽（χ² = 9.227，P = 0.010）、喘息（χ² = 7.273，P = 0.026）和呕吐（χ² = 8.163，P = 0.017）的患病率外，其他临床症状在三种病毒亚型之间相似。在所有ILI儿童中，流感阴性儿童每次流感发作的平均总费用为688.4元（95%CI：630.1 - 746.7）；流感阳性儿童为768.0元（95%CI：686.8 - 849.3），乙型流感儿童为738.3元（95%CI：655.5 - 821.1）。甲型H1N1流感儿童的总费用比甲型H3N2流感或乙型流感儿童高得多（χ² = 7.237，P = 0.028）。感染流感的儿童咳嗽、流涕、喘息、呕吐和惊厥的患病率高于未感染流感的儿童。甲型H1N1流感亚型造成的经济负担比其他两种流感亚型更重。
