Centre for Health Management and Policy Research, School of Public Health, Shandong University, Jinan, China.
NHC Key Lab of Health Economics and Policy Research, Shandong University, Jinan, China.
BMJ Open. 2022 Jun 9;12(6):e055725. doi: 10.1136/bmjopen-2021-055725.
To investigate what factors affect parents' influenza vaccination preference for their children and whether there exists preference heterogeneity among respondents in China.
Cross-sectional study. A discrete choice experiment was conducted. Five attributes were identified based on literature review and qualitative interviews, including protection rate, duration of vaccine-induced protection, risk of serious side effects, location of manufacturer and out-of-pocket cost.
Multistage sampling design was used. According to geographical location and the level of economic development, 10 provinces in China were selected, and the survey was conducted at community healthcare centres or stations.
Parents with at least one child aged between 6 months and 5 years old were recruited and the survey was conducted via a face-to-face interview in 2019. In total, 600 parents completed the survey, and 449 who passed the internal consistency test were included in the main analysis.
A mixed logit model was used to estimate factors affecting parents' preference to vaccinate their children. In addition, sociodemographic characteristics were included to explore the preference heterogeneity.
In general, respondents preferred to vaccinate their children. All attributes were statistically significant and among them, the risk of severe side effects was the most important attribute, followed by the protection rate and duration of vaccine-induced protection. Contrary to our initial expectation, respondents have a stronger preference for the domestic than the imported vaccine. Some preference heterogeneity among parents was also found and in particular, parents who were older, or highly educated placed a higher weight on a higher protection rate.
Vaccination safety and vaccine effectiveness are the two most important characteristics that influenced parents' decision to vaccinate against influenza for their children in China. Results from this study will facilitate future policy implementations to improve vaccination uptake rates.
调查影响父母为子女接种流感疫苗偏好的因素，以及中国受访者中是否存在偏好异质性。
横断面研究。进行了离散选择实验。基于文献回顾和定性访谈确定了 5 个属性，包括保护率、疫苗诱导保护的持续时间、严重副作用风险、制造商所在地和自付费用。
采用多阶段抽样设计。根据地理位置和经济发展水平，在中国选择了 10 个省份，并在社区卫生中心或站点进行了调查。
招募了至少有一名 6 个月至 5 岁子女的父母，并于 2019 年通过面对面访谈进行了调查。共有 600 名父母完成了调查，其中 449 名通过内部一致性测试的父母被纳入主要分析。
使用混合逻辑模型估计影响父母为子女接种疫苗偏好的因素。此外，还纳入了社会人口统计学特征，以探讨偏好异质性。
总体而言，受访者更倾向于为子女接种疫苗。所有属性均具有统计学意义，其中严重副作用风险是最重要的属性，其次是保护率和疫苗诱导保护的持续时间。与我们的初始预期相反，受访者对国产疫苗的偏好强于进口疫苗。还发现了父母之间存在一些偏好异质性，特别是年龄较大或受教育程度较高的父母更看重更高的保护率。
在中国，疫苗接种安全性和疫苗有效性是影响父母为子女接种流感疫苗决定的两个最重要特征。本研究的结果将有助于未来实施提高疫苗接种率的政策。
