Whanger P D, Oh S H
Experientia Suppl. 1979;34:281-91. doi: 10.1007/978-3-0348-6493-0_21.
A number of elements including zinc, cadmium, mercury and copper will enhance the synthesis of MT, but only zinc and cadmium are deposited with this protein at higher levels than with other proteins in the liver when these are given orally. However, mercury and copper are deposited with MT in the kidney regardless of whether given orally or by injection. As the level of zinc is increased in the diet a corresponding increase of zinc concentration occurs only in the MT fraction of tissue cytosols. Zinc disappears from the MT fraction to the supplementation levels within 3 to 4 days when rats which have been fed a high zinc diet are changed to a zinc deficient diet. The evidence indicates that MT is involved with zinc metabolism. The half-life of MT is longer when cadmium is used to induce its synthesis than when zinc is used. Dietary sulfur deficiency limits the synthesis of MT. Various stresses, in which strenuous exercise, cold environment, and CC14 injection were most effective, and infections were found to enhance MT synthesis, suggesting a role for it in the defense mechanism.
包括锌、镉、汞和铜在内的多种元素会增强金属硫蛋白（MT）的合成，但口服这些元素时，只有锌和镉在肝脏中与该蛋白的结合水平高于与其他蛋白质的结合水平。然而，无论口服还是注射，汞和铜都会在肾脏中与MT结合。随着饮食中锌含量的增加，相应的锌浓度升高仅出现在组织胞质溶胶的MT部分。当喂食高锌饮食的大鼠改为缺锌饮食时，锌会在3至4天内从MT部分消失至补充水平。证据表明MT与锌代谢有关。用镉诱导MT合成时，其半衰期比用锌诱导时更长。饮食中硫缺乏会限制MT的合成。各种应激，其中剧烈运动、寒冷环境和注射四氯化碳最为有效，并且发现感染会增强MT合成，这表明MT在防御机制中发挥作用。
