HDAC6 在感染与先天免疫的交汇点。
HDAC6 at Crossroads of Infection and Innate Immunity.
机构信息
Cell-Cell Communication Laboratory, Vascular Pathophysiology Area, Centro Nacional Investigaciones Cardiovasculares (CNIC), Melchor Fernández Almagro 3, Madrid 28029, Spain; Servicio de Inmunología, Hospital Universitario de la Princesa, Instituto de Investigación Sanitaria La Princesa (IIS-IP), Universidad Autónoma de Madrid, Diego de León 62, Madrid 28006, Spain.
Departamento de Biología Molecular, Centro de Biología Molecular 'Severo Ochoa' (CSIC-UAM), Universidad Autónoma de Madrid, Madrid 28049, Spain; CIBER de Enfermedades Cardiovasculares, ISCIII (CIBERCV), 28029 Madrid, Spain.
出版信息
Trends Immunol. 2018 Aug;39(8):591-595. doi: 10.1016/j.it.2018.05.004. Epub 2018 Jun 21.
Histone deacetylase 6 (HDAC6) acts by enzyme-dependent and -independent mechanisms to regulate diverse cellular processes including autophagy, the ubiquitin proteasome system, and cell migration. HDAC6 also has emerging roles in innate immunity, including pathogen sensing and destruction, thus placing this enzyme at the crossroads of infection and innate immunity.
组蛋白去乙酰化酶 6（HDAC6）通过酶依赖性和非依赖性机制来调节多种细胞过程，包括自噬、泛素蛋白酶体系统和细胞迁移。HDAC6 在外源免疫中也具有新兴作用，包括病原体的感知和破坏，因此将该酶置于感染和先天免疫的交叉点。
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