脑特异性组蛋白去乙酰化酶6基因敲低诱导的免疫抑制改善了……的衰老表现
Immunosuppression Induced by Brain-Specific HDAC6 Knockdown Improves Aging Performance in .
作者信息
Zhao Yingying, Xuan Hongwen, Shen Chao, Liu Peiyi, Han Jing-Dong J, Yu Wei
机构信息
State Key Laboratory of Genetic Engineering, School of Life Sciences, Zhongshan Hospital, Fudan University, Shanghai, 200438 China.
CAS Key Laboratory of Computational Biology, Shanghai Institutes for Biological Sciences, CAS-MPG Partner Institute for Computational Biology, Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences, 320 Yue Yang Road, Shanghai, 200031 China.
出版信息
Phenomics. 2022 Feb 23;2(3):194-200. doi: 10.1007/s43657-022-00045-2. eCollection 2022 Jun.
UNLABELLED
HDAC6 is involved in several biological processes related to aging-associated diseases. However, it was unknown whether HDAC6 could directly regulate lifespan and healthspan. We found that HDAC6 knockdown induced transcriptome changes to attenuate the aging changes in the head, particularly on the inflammation and innate immunity-related genes. Whole-body knockdown of HDAC6 extended lifespan in the fly, furthermore brain-specific knockdown of HDAC6 extended both lifespan and healthspan in the fly. Our results established HDAC6 as a lifespan regulator and provided a potential anti-aging target.
SUPPLEMENTARY INFORMATION
The online version contains supplementary material available at 10.1007/s43657-022-00045-2.
未标记
HDAC6参与了与衰老相关疾病有关的多个生物学过程。然而，HDAC6是否能直接调节寿命和健康寿命尚不清楚。我们发现，HDAC6基因敲低诱导转录组变化，以减轻头部的衰老变化，特别是在炎症和先天免疫相关基因上。HDAC6的全身基因敲低延长了果蝇的寿命，此外，HDAC6的脑特异性基因敲低延长了果蝇的寿命和健康寿命。我们的结果确立了HDAC6作为寿命调节因子，并提供了一个潜在的抗衰老靶点。
补充信息
在线版本包含可在10.1007/s43657-022-00045-2获取的补充材料。
Zotero 插件