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口服枸橼酸氯米芬对2只血浆睾酮水平低且精液质量差的犬的治疗效果。

Therapeutic effects of oral clomiphene citrate in 2 dogs with low plasma testosterone levels and poor semen quality.

作者信息

Kobayashi Masanori, Hori Tatsuya, Kawakami Eiichi

机构信息

Laboratory of Reproduction, Faculty of Veterinary Medicine, Nippon Veterinary and Life Science University, 1-7-1 Kyonan-cho, Musashino-shi, Tokyo 180-8602, Japan.

出版信息

J Vet Med Sci. 2018 Aug 10;80(8):1233-1235. doi: 10.1292/jvms.18-0108. Epub 2018 Jun 22.

DOI:10.1292/jvms.18-0108
PMID:29937459
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6115249/
Abstract

Two dogs with low plasma testosterone (T) levels and poor semen quality were administered one tablet of 12.5 mg clomiphene citrate orally per day at 2-day intervals for 4 weeks. Plasma T levels, total sperm count, and sperm motility in both dogs temporarily increased between 3 and 6 weeks after the start of treatment. These results indicate that poor semen quality in dogs with low plasma T level can be improved by oral administration of clomiphene citrate.

摘要

对两只血浆睾酮（T）水平较低且精液质量较差的犬，每隔2天口服1片12.5mg枸橼酸氯米芬，持续4周。在治疗开始后的3至6周内，两只犬的血浆T水平、总精子数和精子活力均暂时升高。这些结果表明，口服枸橼酸氯米芬可改善血浆T水平较低犬的精液质量。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/433c/6115249/ac3e71043cc7/jvms-80-1233-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/433c/6115249/0f2b270bc8c6/jvms-80-1233-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/433c/6115249/7cd822b321dd/jvms-80-1233-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/433c/6115249/d6c0bbb2bdfe/jvms-80-1233-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/433c/6115249/f44a6c30a069/jvms-80-1233-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/433c/6115249/ac3e71043cc7/jvms-80-1233-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/433c/6115249/0f2b270bc8c6/jvms-80-1233-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/433c/6115249/7cd822b321dd/jvms-80-1233-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/433c/6115249/d6c0bbb2bdfe/jvms-80-1233-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/433c/6115249/f44a6c30a069/jvms-80-1233-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/433c/6115249/ac3e71043cc7/jvms-80-1233-g005.jpg

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本文引用的文献

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Andrology. 2015 Sep;3(5):864-7. doi: 10.1111/andr.12086. Epub 2015 Jul 31.
2
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J Vet Med Sci. 2016 Jan;77(12):1711-4. doi: 10.1292/jvms.15-0294. Epub 2015 Aug 2.
3
Differential effects of isomers of clomiphene citrate on reproductive tissues in male mice.
枸橼酸氯米芬异构体对雄性小鼠生殖组织的不同作用。
BJU Int. 2016 Feb;117(2):344-50. doi: 10.1111/bju.13244. Epub 2015 Sep 7.
4
Enclomiphene citrate stimulates testosterone production while preventing oligospermia: a randomized phase II clinical trial comparing topical testosterone.枸橼酸氯米酚刺激睾酮产生，同时预防少精子症：一项比较局部睾酮的随机 II 期临床试验。
Fertil Steril. 2014 Sep;102(3):720-7. doi: 10.1016/j.fertnstert.2014.06.004. Epub 2014 Jul 17.
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J Sex Med. 2013 Jun;10(6):1628-35. doi: 10.1111/jsm.12116. Epub 2013 Mar 26.
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Changes in plasma testosterone level and semen quality after frequent injections of GnRH analogue in a Beagle dog with azoospermia.
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