Gertz H J, Cervos-Navarro J, Frydl V, Schultz F
Mech Ageing Dev. 1985 Jun;31(1):25-35. doi: 10.1016/0047-6374(85)90024-7.
We describe light- and electron-microscopically a new type of intracytoplasmatic inclusions within cell processes of the cerebral cortex and the underlying white matter. These structures measure 5-50 micron in diameter and consist almost exclusively of densely packed alpha- or beta-glycogen granules, which never occur together in any single structure. Within their periphery, electron-dense amorphous spots and cell organelles, especially mitochondria, were seen. No membrane-bound glycogen was observed. We propose to call them granular glycogen bodies. They occur in 4 of 7 examined postmortem specimens of the cerebral cortex of people older than 60 years of age. They were not found in 4 younger controls aged 26-48. Their appearance may reflect a distinct turnover disorder of carbohydrate metabolism, which becomes manifest under diverse pathologic conditions and in the normal aging process.
我们通过光学显微镜和电子显微镜描述了大脑皮质及深层白质细胞突起内一种新型的胞质内包涵体。这些结构直径为5 - 50微米，几乎完全由紧密堆积的α或β糖原颗粒组成，在任何单个结构中它们从不一起出现。在其周边可见电子致密的无定形斑点和细胞器，尤其是线粒体。未观察到有膜包被的糖原。我们提议将它们称为颗粒状糖原小体。它们出现在7例60岁以上人群大脑皮质的尸检标本中的4例。在4例年龄为26 - 48岁的年轻对照中未发现。它们的出现可能反映了碳水化合物代谢的一种独特的周转紊乱，这种紊乱在多种病理状况及正常衰老过程中表现出来。
