Takemori N, Hirai K, Onodera R, Saito N, Kamiguchi K, Namiki M
Third Department of Internal Medicine, Asahikawa Medical College, Japan.
Leuk Lymphoma. 1993 Oct;11(3-4):309-14. doi: 10.3109/10428199309087010.
We present a unique case of crisis type chronic adult T-cell leukemia (ATL), in which the majority of leukemic cells had abundant periodic acid-Schiff (PAS)-positive cytoplasmic inclusions. These inclusions were found to be composed of glycogen because the PAS-positivity completely disappeared after digestion with amylase or human saliva. Electron microscopy also revealed that the inclusions consisted of aggregated beta particles of glycogen. The mechanism of glycogen accumulation in leukemic cells remains unknown; however, the presence of such inclusions in leukemic cells may be helpful diagnostically in T-lymphocyte malignancies.
我们报告了一例独特的危象型慢性成人T细胞白血病（ATL），其中大多数白血病细胞具有丰富的过碘酸希夫（PAS）阳性细胞质包涵体。这些包涵体被发现由糖原组成，因为在用淀粉酶或人唾液消化后，PAS阳性完全消失。电子显微镜检查还显示，这些包涵体由糖原的聚集β颗粒组成。白血病细胞中糖原积累的机制尚不清楚；然而，白血病细胞中存在此类包涵体可能有助于T淋巴细胞恶性肿瘤的诊断。
