血管紧张素转换酶插入/缺失多态性与川崎病易感性：一项荟萃分析。
Angiotensin-converting enzyme insertion/deletion polymorphism and susceptibility to Kawasaki disease: a meta-analysis.
作者信息
Pan Yan, Lu Hongzhu
机构信息
Department of Pediatrics, the First Affiliated Hospital of Yangtze University, Jingzhou, Hubei Province, China.
Medical College of Yangtze University, Jingzhou, Hubei Province, China.
出版信息
Afr Health Sci. 2017 Dec;17(4):991-999. doi: 10.4314/ahs.v17i4.6.
BACKGROUND
The angiotensin-converting enzyme (ACE) I/D polymorphism has been reported to be associated with Kawasaki disease (KD), but studies to date present conflicting results.
OBJECTIVES
The aim of this study is to derive a more precise estimation of the association between the ACE I/D polymorphism and KD risk.
METHODS
PubMed, EMBASE, CNKI and Wangfang databases were retrievaled to identify for relevant studies from inception to May 2017. Pooled odds ratios (OR) with 95% confidence intervals (CI) were calculated using Stata 12.0 software.
RESULTS
A total of 6 case-control studies comprising 634 patients and 458 controls were included in the meta-analysis, and we found a significant association between the ACE I/D polymorphism and KD risk (D vs I:OR = 0.81, 95%CI = 0.31-2.11;DD vs II: OR = 1.03, 95%CI = 0.42-2.54; DI vs II: OR = 1.44, 95%CI = 1.09-1.90; dominant model: OR = 1.43, 95%CI = 1.11-1.85; recessive model: OR = 1.21, 95%CI = 0.44-3.29 ). When stratified by sample size>200, this polymorphism is associated with an increased the risk of KD.
CONCLUSION
The I/D polymorphism in the ACE gene may be associated with susceptibility to KD.
背景
据报道，血管紧张素转换酶（ACE）I/D多态性与川崎病（KD）相关，但迄今为止的研究结果相互矛盾。
目的
本研究旨在更精确地评估ACE I/D多态性与KD风险之间的关联。
方法
检索PubMed、EMBASE、CNKI和万方数据库，以确定从创刊至2017年5月的相关研究。使用Stata 12.0软件计算合并比值比（OR）及其95%置信区间（CI）。
结果
荟萃分析共纳入6项病例对照研究，包括634例患者和458例对照，我们发现ACE I/D多态性与KD风险之间存在显著关联（D vs I：OR = 0.81，95%CI = 0.31 - 2.11；DD vs II：OR = 1.03，95%CI = 0.42 - 2.54；DI vs II：OR = 1.44，95%CI = 1.09 - 1.90；显性模型：OR = 1.43，95%CI = 1.11 - 1.85；隐性模型：OR = 1.21，95%CI = 0.44 - 3.29）。按样本量>200分层时，这种多态性与KD风险增加相关。
结论
ACE基因中的I/D多态性可能与KD易感性相关。
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