Pan Yan, Lu Hongzhu
Department of Pediatrics, the First Affiliated Hospital of Yangtze University, Jingzhou, Hubei Province, China.
Medical College of Yangtze University, Jingzhou, Hubei Province, China.
Afr Health Sci. 2017 Dec;17(4):991-999. doi: 10.4314/ahs.v17i4.6.
The angiotensin-converting enzyme (ACE) I/D polymorphism has been reported to be associated with Kawasaki disease (KD), but studies to date present conflicting results.
The aim of this study is to derive a more precise estimation of the association between the ACE I/D polymorphism and KD risk.
PubMed, EMBASE, CNKI and Wangfang databases were retrievaled to identify for relevant studies from inception to May 2017. Pooled odds ratios (OR) with 95% confidence intervals (CI) were calculated using Stata 12.0 software.
A total of 6 case-control studies comprising 634 patients and 458 controls were included in the meta-analysis, and we found a significant association between the ACE I/D polymorphism and KD risk (D vs I:OR = 0.81, 95%CI = 0.31-2.11;DD vs II: OR = 1.03, 95%CI = 0.42-2.54; DI vs II: OR = 1.44, 95%CI = 1.09-1.90; dominant model: OR = 1.43, 95%CI = 1.11-1.85; recessive model: OR = 1.21, 95%CI = 0.44-3.29 ). When stratified by sample size>200, this polymorphism is associated with an increased the risk of KD.
The I/D polymorphism in the ACE gene may be associated with susceptibility to KD.
据报道，血管紧张素转换酶（ACE）I/D多态性与川崎病（KD）相关，但迄今为止的研究结果相互矛盾。
本研究旨在更精确地评估ACE I/D多态性与KD风险之间的关联。
检索PubMed、EMBASE、CNKI和万方数据库，以确定从创刊至2017年5月的相关研究。使用Stata 12.0软件计算合并比值比（OR）及其95%置信区间（CI）。
荟萃分析共纳入6项病例对照研究，包括634例患者和458例对照，我们发现ACE I/D多态性与KD风险之间存在显著关联（D vs I：OR = 0.81，95%CI = 0.31 - 2.11；DD vs II：OR = 1.03，95%CI = 0.42 - 2.54；DI vs II：OR = 1.44，95%CI = 1.09 - 1.90；显性模型：OR = 1.43，95%CI = 1.11 - 1.85；隐性模型：OR = 1.21，95%CI = 0.44 - 3.29）。按样本量>200分层时，这种多态性与KD风险增加相关。
ACE基因中的I/D多态性可能与KD易感性相关。
