通过三聚体分子信标传感器对 microRNA 单核苷酸变体进行多重区分。

Multiplexed discrimination of microRNA single nucleotide variants through triplex molecular beacon sensors.

机构信息

School of Resource and Environmental Engineering, Hefei University of Technology, Hefei 230009, China.

出版信息

Chem Commun (Camb). 2018 Jul 5;54(55):7673-7676. doi: 10.1039/c8cc03574a.

Abstract

Herein, we develop a new nanopore sensing strategy for the selective detection of microRNAs and single nucleotide variants (SNVs) based on triplex molecular beacon sensors. This sensing system shows very high specificity in discriminating microRNA SNVs and can be applied for the simultaneous detection of several microRNAs of the same family in a mixture.

摘要

在此，我们开发了一种新的基于三聚体分子信标的纳米孔传感策略，用于选择性检测 microRNAs 和单核苷酸变体 (SNVs)。该传感系统在区分 microRNA SNVs 方面表现出非常高的特异性，并且可用于混合物中同一家族的几个 microRNAs 的同时检测。