癌症代谢：当前的认识和疗法。
Cancer Metabolism: Current Understanding and Therapies.
机构信息
Departments of Chemistry, Molecular and Cell Biology, and Nutritional Sciences and Toxicology , University of California, Berkeley , Berkeley , California 94720 , United States.
出版信息
Chem Rev. 2018 Jul 25;118(14):6893-6923. doi: 10.1021/acs.chemrev.7b00775. Epub 2018 Jun 25.
Dysregulation of cancer cell metabolism contributes to abnormal cell growth, the biological end point of cancer. We review here numerous affected oncogenes and metabolic pathways common in cancer and how they contribute to cancer pathogenesis and malignancy. This review also discusses various pharmacological manipulations that take advantage of these metabolic abnormalities and the current targeted therapies that have arisen from this research.
癌细胞代谢的失调导致了异常的细胞生长，这是癌症的生物学终点。我们在这里回顾了许多在癌症中常见的受影响的癌基因和代谢途径，以及它们如何导致癌症的发病机制和恶性程度。这篇综述还讨论了利用这些代谢异常的各种药理学干预措施，以及由此产生的当前靶向治疗。
Zotero 插件