血浆热休克蛋白 90-α在早期结直肠癌诊断中有优势。
Plasma heat shock protein 90-alpha have an advantage in diagnosis of colorectal cancer at early stage.
机构信息
University of Jinan, Clinical Laboratory of Shandong Cancer Hospital Affiliated to Shandong University, PR China.
School of Medicine and Life Sciences, University of Jinan, Shandong Academy of Medicine, PR China.
出版信息
Biomark Med. 2018 Aug;12(8):881-890. doi: 10.2217/bmm-2018-0155. Epub 2018 Jun 25.
AIM
We investigated HSP90α as screening biomarker for early colorectal cancer (CRC).
METHODS & RESULTS: Seventy-seven CRC patients and 78 healthy controls were enrolled. Plasma HSP90α was significantly higher in CRC patients than in healthy controls (p < 0.05). levels were higher in late (stages III and IV) CRC than in early (stages I and II) CRC (p = 0.022). HSP90α conferred an advantage in the diagnosis of early CRC. Combination of HSP90α and carcinoembryonic antigen improved the diagnostic sensitivity (84.4%) and specificity (89.5%) for CRC (area under the curve: 0.968); for early CRC, the sensitivity was 82.5% and specificity was 89.5% (area under the curve: 0.955).
CONCLUSION
HSP90 is a potential biomarker for the diagnosis of early CRC.
目的
我们研究 HSP90α 作为早期结直肠癌（CRC）的筛查生物标志物。
方法和结果
共纳入 77 例 CRC 患者和 78 例健康对照者。CRC 患者的血浆 HSP90α 明显高于健康对照组（p<0.05）。晚期（III 期和 IV 期）CRC 患者的水平高于早期（I 期和 II 期）CRC（p=0.022）。HSP90α 在早期 CRC 的诊断中具有优势。HSP90α 和癌胚抗原联合检测提高了 CRC 的诊断敏感性（84.4%）和特异性（89.5%）（曲线下面积：0.968）；对于早期 CRC，敏感性为 82.5%，特异性为 89.5%（曲线下面积：0.955）。
结论
HSP90 是早期 CRC 诊断的潜在生物标志物。
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