一种人类普通感冒病毒的结构及其与其他小核糖核酸病毒的功能关系。

Structure of a human common cold virus and functional relationship to other picornaviruses.

作者信息

Rossmann M G, Arnold E, Erickson J W, Frankenberger E A, Griffith J P, Hecht H J, Johnson J E, Kamer G, Luo M, Mosser A G

出版信息

Nature. 1985;317(6033):145-53. doi: 10.1038/317145a0.

DOI:10.1038/317145a0

PMID:2993920

Abstract

We report the first atomic resolution structure of an animal virus, human rhinovirus 14. It is strikingly similar to known icosahedral plant RNA viruses. Four neutralizing immunogenic regions have been identified. These, and corresponding antigenic sequences of polio and foot-and-mouth disease viruses, reside on external protrusions. A large cleft on each icosahedral face is probably the host cell receptor binding site.

摘要

我们报道了动物病毒——人鼻病毒14的首个原子分辨率结构。它与已知的二十面体植物RNA病毒惊人地相似。已确定了四个中和免疫原性区域。这些区域以及脊髓灰质炎病毒和口蹄疫病毒的相应抗原序列位于外部突起上。每个二十面体面上的一个大裂缝可能是宿主细胞受体结合位点。