School of Chemistry, University of Manchester, Oxford Road, M13 9PL, UK.
Laboratory of Organic Chemistry, Wageningen University, P.O. Box 8026, 6700EG, Wageningen, The Netherlands.
Angew Chem Int Ed Engl. 2019 Jan 28;58(5):1280-1307. doi: 10.1002/anie.201806297. Epub 2018 Dec 3.
Construction of discrete, self-assembled architectures in water has gained significant interest in recent years as a wide range of applications arises from their defined 3D structure. In this review we jointly discuss the efforts of supramolecular chemists and biotechnologists who previously worked independently, to tackle discipline-specific challenges associated with construction of assemblies from synthetic and bio-derived components, respectively. Going forward, a more interdisciplinary research approach will expedite development of complexes with real-world applications that exploit the benefits of compartmentalisation. In support of this, we summarise advances made in the development of discrete, water-soluble assemblies, with particular focus on their current and prospective applications. Areas where understanding and methodologies can be transferred from one sector to the adjacent field are highlighted in anticipation this will yield advances not possible from either field alone.
近年来，离散的自组装结构在水中的构建引起了广泛关注，因为它们的三维结构可以定义广泛的应用。在这篇综述中，我们共同讨论了超分子化学家和生物技术专家的努力，他们以前是各自独立工作的，分别解决了与合成和生物衍生组件组装相关的特定学科的挑战。展望未来，更具跨学科研究方法将加快具有利用分区优势的实际应用的复杂体系的发展。为此，我们总结了在开发离散的水溶性组装体方面取得的进展，特别关注它们当前和潜在的应用。我们强调了在一个领域中理解和方法可以转移到相邻领域的领域，预计这将带来仅从一个领域无法实现的进展。
