Nardoni A, Di Piazza V, Marchetti E, Geatti O, Cedaro P, Lattuada L
Minerva Med. 1985 Sep 15;76(34-35):1535-40.
Urinary cyclic adenosine monophosphate (AMP-c) was measured morning and evening in 35 patients with alcohol withdrawal syndrome (AWS). 65% of the patients revealed a higher night time than day time concentration of AMP-c in the urine, reflecting increased sympathetic adrenergic activity. The circadian rhythm was lost in 88.55% of the 35 patients. The pathogenic factors and mechanisms involved in AWS are discussed and the contribution of sympathetic adrenergic hyperactivity to the onset of the withdrawal syndrome with its concomitant depression of the cholinergic and GABAergic systems is emphasised. Finally it is suggested that insomnia and the loss of REM sleep may also contribute to the onset of the condition.
对35例酒精戒断综合征（AWS）患者早晚测量尿中环磷酸腺苷（AMP-c）。65%的患者尿中AMP-c夜间浓度高于白天，反映交感肾上腺素能活性增加。35例患者中88.55%的昼夜节律消失。讨论了AWS的致病因素和机制，并强调了交感肾上腺素能亢进对戒断综合征发作的作用及其伴随的胆碱能和γ-氨基丁酸能系统抑制。最后指出，失眠和快速眼动睡眠丧失也可能促成该病的发作。
