Desai Rupak, Patel Upenkumar, Sharma Shobhit, Singh Sandeep, Doshi Shreyans, Shaheen Sana, Shamim Sofia, Korlapati Lakshmi Shirisha, Balan Shuba, Bray Christopher, Williams Renee, Shah Nihar
Department of Public Health, National University, San Diego, CA.
Department of Biology, Texas State University, San Marcos, TX.
Pancreas. 2018 Aug;47(7):849-855. doi: 10.1097/MPA.0000000000001095.
The aim of this study was to assess the role of hepatitis B (HepB) infection in the causation of pancreatic cancer and the predictors of pancreatic cancer and mortality.
We identified pancreatic cancer patients 11 to 70 years of age from the 2013-2014 National Inpatient Sample. Pearson χ test and Student's t-test were used for categorical and continuous variables, respectively. We assessed the association of HepB and pancreatic cancer and the independent mortality predictors by multivariate analyses.
Of 69,210 pancreatic cancer patients, 175 patients with a history of HepB and 69,035 patients without a history of HepB were identified. Compared with the pancreatic cancer-non-HepB group, the pancreatic cancer-HepB group consisted more of younger (mean, 60.4 [standard deviation, 7.4] years vs 68.2 [standard deviation, 12.1] years), male, black, and Asian patients with low household income and nonelective admissions. The odds of developing pancreatic cancer among the HepB patients were significantly higher (adjusted odds ratio, 1.24; 95% confidence interval, 1.056-1.449; P = 0.008). Black race, age ≥ 65 years, and male sex demonstrated greater odds of mortality.
This study concluded up to a 24% increased likelihood of pancreatic cancer among the HepB patients. Blacks showed greater odds of pancreatic cancer and related mortality.
本研究旨在评估乙型肝炎（HepB）感染在胰腺癌病因中的作用以及胰腺癌和死亡率的预测因素。
我们从2013 - 2014年全国住院患者样本中确定了年龄在11至70岁之间的胰腺癌患者。分别使用Pearson χ检验和Student t检验来分析分类变量和连续变量。我们通过多变量分析评估了HepB与胰腺癌的关联以及独立的死亡率预测因素。
在69210例胰腺癌患者中，确定了175例有HepB病史的患者和69035例无HepB病史的患者。与非HepB胰腺癌组相比，HepB胰腺癌组中年龄较小（平均年龄，60.4[标准差，7.4]岁对68.2[标准差，12.1]岁）、男性、黑人、亚洲人、家庭收入低且为非选择性入院的患者更多。HepB患者患胰腺癌的几率显著更高（调整后的优势比，1.24；95%置信区间，1.056 - 1.449；P = 0.008）。黑人种族、年龄≥65岁和男性的死亡几率更高。
本研究得出结论，HepB患者患胰腺癌的可能性增加了24%。黑人患胰腺癌及相关死亡率的几率更高。
