Gingras Benjamin, Braun Claude M J
Université du Québec à Montréal, Department of Psychology, 100 Sherbrooke St. W., Montreal, Qc H2X 3P2, Canada.
Epilepsy Behav. 2018 Aug;85:129-140. doi: 10.1016/j.yebeh.2018.05.045. Epub 2018 Jun 22.
In patients with cortical lesions, the structure of intelligence has never been studied as a function of age at lesion onset and presence vs absence of lesional epilepsy over the life span.
Two thousand one hundred eighty-six cases were assembled bearing unilateral cortical lesions occurring at all ages (1301 with seizures) with postlesion verbal intelligence quotient (IQ) (VIQ) and performance IQ (PIQ).
Global IQ significantly and constantly decreased as a function of age at lesion onset in the cases without epilepsy, and increased in the cases with epilepsy. Beyond the lesion onset age of 12 years, VIQ was significantly higher than PIQ in the cases without epilepsy, and lower in the cases with epilepsy. The VIQ/PIQ × lesion-side interaction indicative of hemispheric specialization increased significantly linearly with age at lesion onset in the patients without epilepsy but ceased to progress at the lesion-onset age of 30 years and beyond in the cases with epilepsy.
Postlesion global IQ, the difference between VIQ and PIQ, and the laterality index all vary significantly as a function of age at lesion onset. In addition, these changes over the life span are all quite different between cases with and without epilepsy.
在患有皮质病变的患者中，从未研究过智力结构与病变发作时的年龄以及一生中是否存在病变性癫痫之间的关系。
收集了2186例各年龄段出现单侧皮质病变的病例（1301例有癫痫发作），并记录了病变后的言语智商（IQ）（VIQ）和操作智商（PIQ）。
在无癫痫的病例中，总体智商随着病变发作时的年龄显著且持续下降，而在有癫痫的病例中则升高。在病变发作年龄超过12岁后，无癫痫病例的VIQ显著高于PIQ，而有癫痫病例的VIQ则较低。在无癫痫的患者中，表明半球特化的VIQ/PIQ×病变侧交互作用随着病变发作时的年龄显著线性增加，但在有癫痫的病例中，在病变发作年龄达到30岁及以上时停止进展。
病变后的总体智商、VIQ与PIQ之间的差异以及偏侧性指数均随着病变发作时的年龄而显著变化。此外，有癫痫和无癫痫的病例在一生中的这些变化差异很大。
