Department of Psychiatry, Usak University Education and Research Hospital, Usak, Turkey.
Department of Psychiatry, Faculty of Medicine, Suleyman Demirel University, Isparta, Turkey.
Psychiatry Res. 2018 Sep;267:272-276. doi: 10.1016/j.psychres.2018.05.086. Epub 2018 Jun 8.
The best known effects of nesfatin-1 are on appetite and metabolic regulation. Moreover, several research suggest that nesfatin-1 play a role in stress responses. This molecule may be involved in the pathophysiology of mood disorders and suicidal behavior. We compared nesfatin-1 levels between depressed patients with suicidal ideation (n = 32, mean ± SD, 1,40 ± 0.11), without suicidal ideation(n = 31, 1.46 ± 0.14) and healthy controls (n = 32, 1.52 ± 0.13). Suicidal ideation was assessed with the Suicide Probability Scale, Scale for Suicide Ideation and depressive symptoms were evaluated with the Hamilton Depression Rating Scale. Blood samples were collected to measure serum nesfatin-1levels by using ELISA method. The study revealed that serum nesfatin-1 levels were significantly lower in MDD with suicidal ideation than in healthy volunteers (p < 0.001). There were a negative correlation between the scores of suicidal ideation and nesfatin-1 levels in MDD with SI group (r = -0.215; p = 0.016). In the future, nesfatin-1 levels may one day be applied in predicting and monitoring patients' suicide risk. Further prospective studies are required to elucidate this potential association.
内脂素-1 最广为人知的作用是调节食欲和代谢。此外，多项研究表明内脂素-1 在应激反应中发挥作用。这种分子可能与心境障碍和自杀行为的病理生理学有关。我们比较了有自杀意念的抑郁患者（n=32，平均值±标准差，1.40±0.11）、无自杀意念的抑郁患者（n=31，1.46±0.14）和健康对照组（n=32，1.52±0.13）之间的内脂素-1 水平。自杀意念通过自杀可能性量表进行评估，自杀意念评分和抑郁症状通过汉密尔顿抑郁评定量表进行评估。采集血样，采用 ELISA 法测定血清内脂素-1 水平。研究表明，有自杀意念的 MDD 患者的血清内脂素-1 水平明显低于健康志愿者（p<0.001）。在有 SI 组的 MDD 中，自杀意念评分与内脂素-1 水平呈负相关（r=-0.215；p=0.016）。将来，内脂素-1 水平可能有一天会应用于预测和监测患者的自杀风险。需要进一步的前瞻性研究来阐明这种潜在的关联。
