Folescu Roxana, Levai Codrina Mihaela, Grigoraş Mirela Loredana, Arghirescu Teodora Smaranda, Talpoş Ioana Cristina, Gîndac Ciprian Mihai, Zamfir Carmen Lăcrămioara, Poroch Vladimir, Anghel Mirella Dorina
Discipline of Anatomy and Embryology, "Victor Babes" University of Medicine and Pharmacy, Timisoara, Romania;
Rom J Morphol Embryol. 2018;59(1):227-233.
Ki-67 parameter is a proliferation marker in malignant tumors. The increased proliferation activity and the decreased prognosis in lung cancer determined us to investigate different parameters connected to the tumor's aggression, such as cellularity, Ki-67 positivity rate, and proliferating cell nuclear antigen (PCNA). We evaluated the proliferative activity in 62 primary lung tumors by determining the cell's percentage of Ki-67 and immunoreactive PCNA (using MIB-1 and PCNA monoclonal antibodies), classifying Ki-67 and PCNA immunoreactivity into three score groups. The results obtained emphasized a linkage between Ki-67 score with the histological tumor subtype, tumor cellularity and degree of differentiation and with other proliferation immunohistochemistry (IHC) markers, such as p53 cellular tumor antigen. The tumor's cellularity, the Ki-67 positivity rate and PCNA, together with the clinical stage and the histological differentiation bring extra pieces of useful information in order to anticipate the evolution and the prognosis of lung cancer.
Ki-67参数是恶性肿瘤中的一种增殖标志物。肺癌中增殖活性增加且预后降低，这促使我们研究与肿瘤侵袭相关的不同参数，如细胞密度、Ki-67阳性率和增殖细胞核抗原（PCNA）。我们通过测定Ki-67和免疫反应性PCNA的细胞百分比（使用MIB-1和PCNA单克隆抗体），将Ki-67和PCNA免疫反应性分为三个评分组，评估了62例原发性肺肿瘤的增殖活性。所得结果强调了Ki-67评分与肿瘤组织学亚型、肿瘤细胞密度和分化程度以及与其他增殖免疫组化（IHC）标志物（如p53细胞肿瘤抗原）之间的联系。肿瘤的细胞密度、Ki-67阳性率和PCNA，连同临床分期和组织学分化，为预测肺癌的进展和预后提供了额外的有用信息。
