Teixeira Renata Nakata, Dos Santos Leite Gerson, Gorjao Renata, Palmeira Patricia, Santos Cesar Miguel Momesso, Zambonatto Raquel, de Oliveira Heloisa Helena, Levada Adriana Cristina, Fiks Iara Nely, Carvalho Celso Ricardo Fernandes
Department of Physical Therapy, University of Sao Paulo, SP, Brazil.
Institute of Physical Activity Sciences and Sports, Post-Graduation Program in Human Movement Sciences, University Cruzeiro do Sul, Sao Paulo, Brazil.
Int J Sports Med. 2018 Sep;39(9):720-725. doi: 10.1055/a-0633-9001. Epub 2018 Jun 25.
The present study aimed to compare the immune and inflammatory responses between atopic (n=20) and non-atopic (n=39) elite endurance athletes. Fifty-nine elite runners and triathletes were assessed for the following measurements: Th, Th and lymphocyte phenotyping and plasma levels of cortisol, chemokines, inflammatory cytokines and specific immunoglobulin E (IgE). Levels of salivary IgA, allergic symptoms and training data were also evaluated. No difference was observed in baseline lymphocyte levels. However, the Th lymphocytes of atopic athletes presented a lower response after activation. In contrast to this result, levels of salivary IgA and CXCL9 chemokine were higher in the atopic athletes. It was observed that the volume of training per week was linearly associated with Th levels, allergic symptoms and IgE levels. In addition, linear multiple regression analysis demonstrated that the volume of training was the only factor associated with allergic symptoms in atopic athletes (r=0.53; p=0.04). These results suggest that compared to non-atopic athletes, atopic athletes present a reduced Th response and higher levels of salivary IgA. Training volume is associated with the immune response and allergic symptoms, which suggests that they may play a role in the atopy in elite endurance athletes.
本研究旨在比较特应性（n = 20）和非特应性（n = 39）优秀耐力运动员之间的免疫和炎症反应。对59名优秀跑步运动员和铁人三项运动员进行了以下测量：Th、Th和淋巴细胞表型分析以及血浆皮质醇、趋化因子、炎症细胞因子和特异性免疫球蛋白E（IgE）水平。还评估了唾液IgA水平、过敏症状和训练数据。在基线淋巴细胞水平上未观察到差异。然而，特应性运动员的Th淋巴细胞在激活后反应较低。与该结果相反，特应性运动员的唾液IgA和CXCL9趋化因子水平较高。观察到每周训练量与Th水平、过敏症状和IgE水平呈线性相关。此外，线性多元回归分析表明，训练量是与特应性运动员过敏症状相关的唯一因素（r = 0.53；p = 0.04）。这些结果表明，与非特应性运动员相比，特应性运动员的Th反应降低，唾液IgA水平较高。训练量与免疫反应和过敏症状相关，这表明它们可能在优秀耐力运动员的特应性中起作用。
