The Primary Care Unit, Institute of Public Health, University of Cambridge School of Clinical Medicine, Box 113 Cambridge Biomedical Campus, Cambridge, CB2 0SR, UK.
MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, CB2 0QQ, UK.
BMC Public Health. 2018 Jun 26;18(1):796. doi: 10.1186/s12889-018-5712-2.
Cancer is a leading cause of mortality and morbidity worldwide. Prevention is recognised by many, including the World Health Organization, to offer the most cost-effective long-term strategy for the control of cancer. One approach that focuses on individuals is the provision of personalised risk information. However, whether such information motivates behaviour change and whether the effect is different with varying formats of risk presentation is unclear. We aim to assess the short-term effect of providing information about personalised risk of cancer in three different formats alongside lifestyle advice on health-related behaviours, risk perception and risk conviction.
In a parallel group, randomised controlled trial 1000 participants will be recruited through the online platform Prolific. Participants will be allocated to either a control group receiving cancer-specific lifestyle advice alone or one of three intervention groups receiving the same lifestyle advice alongside their estimated 10-year risk of developing one of the five most common preventable cancers, calculated from self-reported modifiable behavioural risk factors, in one of three different formats (bar chart, pictograph or qualitative scale). The primary outcome is change from baseline in computed risk relative to an individual with a recommended lifestyle at three months. Secondary outcomes include: perceived risk of cancer; anxiety; cancer-related worry; intention to change behaviour; and awareness of cancer risk factors.
This study will provide evidence on the short-term effect of providing online information about personalised risk of cancer alongside lifestyle advice on risk perception and health-related behaviours and inform the development of interventions.
ISRCTN17450583. Registered 30 January 2018.
癌症是全球范围内导致死亡和发病的主要原因。许多人包括世界卫生组织都认识到，预防是控制癌症的最具成本效益的长期策略。关注个体的一种方法是提供个性化的风险信息。然而，这种信息是否能激励行为改变，以及不同形式的风险呈现方式是否会产生不同的效果尚不清楚。我们旨在评估提供三种不同格式的个人癌症风险信息以及关于健康相关行为、风险感知和风险信念的生活方式建议对短期效果。
在一项平行组、随机对照试验中，将通过在线平台 Prolific 招募 1000 名参与者。参与者将被分配到对照组，仅接受针对癌症的特定生活方式建议，或接受三种干预组之一，除了相同的生活方式建议外，还收到其估计的 10 年发展五种最常见可预防癌症之一的风险，该风险来自自我报告的可改变行为风险因素，以三种不同格式之一（条形图、图表或定性量表）计算。主要结果是与推荐生活方式个体的基线相比，三个月时计算的风险的变化。次要结果包括：癌症风险感知；焦虑；癌症相关担忧；改变行为的意图；以及对癌症风险因素的认识。
本研究将提供关于提供在线个人癌症风险信息以及关于风险感知和健康相关行为的生活方式建议的短期效果的证据，并为干预措施的制定提供信息。
ISRCTN85141153。于 2018 年 1 月 30 日注册。
