Tonew M, Tonew E
Virologie. 1985 Apr-Jun;36(2):103-9.
A number of 3108 new synthetic compounds were subjected to a screening for antiviral activity. The screening resulted in the selection of numerous drugs active against mengovirus in vitro. Some drugs were also active against Coxsackie viruses A9 and B1; most of the drugs efficient against Coxsackie virus A9 also showed activity against mengovirus. Quantitative investigations--such as the determination of a therapeutic index or of the inhibition of infectious virus yields in one-step growth cycle experiments--allowed the selection of the compounds with the highest in vitro efficacy.
对3108种新合成化合物进行了抗病毒活性筛选。筛选结果选出了许多在体外对脑心肌炎病毒有活性的药物。一些药物对柯萨奇病毒A9和B1也有活性；大多数对柯萨奇病毒A9有效的药物对脑心肌炎病毒也有活性。定量研究——如在一步生长周期实验中测定治疗指数或抑制感染性病毒产量——有助于选出体外效力最高的化合物。
