双嘧达莫衍生物的抗病毒活性。
Antiviral activity of dipyridamole derivatives.
作者信息
Tonew M, Laass W, Tonew E, Franke R, Goldner H, Zschiesche W
出版信息
Acta Virol. 1978 Jul;22(4):287-95.
Among 46 novel pyrimido [5.4-d] pyrimidine derivatives, 26 compounds were found to exhibit antiviral activity as revealed in a test programme against Mengo, Coxsackie B1, fowl plague, vaccinia and pseudorabies viruses, as concerns inhibition of plaque formation and of infectious virus yield. Attempts to disclose structure-activity relationships by discriminant analysis pointed to a possible importance of hydrophobic substitution for the antiviral effectiveness against Mengo virus of the derivatives investigated.
在46种新型嘧啶并[5.4 - d]嘧啶衍生物中，在针对门戈病毒、柯萨奇B1病毒、禽痘病毒、牛痘病毒和伪狂犬病病毒的测试程序中发现，有26种化合物表现出抗病毒活性，涉及对噬斑形成和感染性病毒产量的抑制。通过判别分析揭示构效关系的尝试表明，疏水取代对于所研究衍生物针对门戈病毒的抗病毒效力可能具有重要意义。
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