Department of Pharmacognosy and Biomaterials, Poznan University of Medical Sciences, Rokietnicka 3, 60-806 Poznan, Poland.
Department of Medical Chemistry and Laboratory Medicine, Poznan University of Medical Sciences, Rokietnicka 8, 60-806 Poznan, Poland.
Int J Mol Sci. 2024 Jun 25;25(13):6937. doi: 10.3390/ijms25136937.
Cancer remains a significant global health challenge, with millions of deaths attributed to it annually. Radiotherapy, a cornerstone in cancer treatment, aims to destroy cancer cells while minimizing harm to healthy tissues. However, the harmful effects of irradiation on normal cells present a formidable obstacle. To mitigate these effects, researchers have explored using radioprotectors and mitigators, including natural compounds derived from secondary plant metabolites. This review outlines the diverse classes of natural compounds, elucidating their roles as protectants of healthy cells. Furthermore, the review highlights the potential of these compounds as radioprotective agents capable of enhancing the body's resilience to radiation therapy. By integrating natural radioprotectors into cancer treatment regimens, clinicians may improve therapeutic outcomes while minimizing the adverse effects on healthy tissues. Ongoing research in this area holds promise for developing complementary strategies to optimize radiotherapy efficacy and enhance patient quality of life.
癌症仍然是一个重大的全球健康挑战，每年有数百万的人因此而死亡。放射治疗是癌症治疗的基石，旨在摧毁癌细胞，同时最大限度地减少对健康组织的伤害。然而，辐射对正常细胞的有害影响是一个巨大的障碍。为了减轻这些影响，研究人员已经探索使用放射保护剂和缓和剂，包括来自次生植物代谢物的天然化合物。本综述概述了不同类别的天然化合物，阐明了它们作为健康细胞保护剂的作用。此外，该综述还强调了这些化合物作为放射保护剂的潜力，它们能够增强身体对放射治疗的抵抗力。通过将天然放射保护剂整合到癌症治疗方案中，临床医生可以提高治疗效果，同时最大限度地减少对健康组织的不良反应。该领域的持续研究为开发补充策略以优化放射治疗效果和提高患者生活质量提供了希望。
