聚（PEGMA-r-Phosmer）涂层修饰的钛合金表面的细菌抑制和成骨细胞黏附。
Bacterial Inhibition and Osteoblast Adhesion on Ti Alloy Surfaces Modified by Poly(PEGMA- r-Phosmer) Coating.
机构信息
Department of Chemical Engineering, Graduate School of Engineering , Kyushu University , 744 Motooka , Nishi-ku, Fukuoka 819-0395 , Japan.
Center for Nano Materials and Technology , Japan Advanced Institute of Science and Technology , 1-1 Asahidai , Nomi , Ishikawa 923-1292 , Japan.
出版信息
ACS Appl Mater Interfaces. 2018 Jul 18;10(28):23674-23681. doi: 10.1021/acsami.8b07757. Epub 2018 Jul 5.
We have synthesized and immobilized PEGMA-Phosmer to Ti6Al4V surfaces by a simple procedure to reduce bacteria-associated infection without degrading the cell response. Adhered bacteria coverage was lessened to 1% on polymer-coated surfaces when exposed to Escherichia coli, Staphylococcus epidermidis, and Streptococcus mutans. Moreover, PEGMA-Phosmer and homoPhosmer coatings presented better responses to MC3T3-E1 preosteoblast cells when compared with the results for PEGMA-Phosmer-coated and raw Ti alloy surfaces. The behavior of balancing bacterial inhibition and cell attraction of the PEGMA-Phosmer coating was explained by the grafted phosphate groups, with an appropriate PEG brush length facilitating greater levels of calcium deposition and further fibronectin adsorption when compared with that of the raw Ti alloy surface.
我们通过简单的程序合成并固定聚乙二醇甲基丙烯酸酯-膦酸酯到 Ti6Al4V 表面，以减少细菌相关感染，同时不降低细胞反应。当暴露于大肠杆菌、表皮葡萄球菌和变形链球菌时，聚合物涂层表面上的粘附细菌覆盖率减少到 1%。此外，与聚乙二醇甲基丙烯酸酯-膦酸酯涂层和原始钛合金表面的结果相比，PEGMA-Phosmer 和 homoPhosmer 涂层对 MC3T3-E1 前成骨细胞表现出更好的反应。通过接枝的磷酸基团解释了聚乙二醇甲基丙烯酸酯-膦酸酯涂层平衡细菌抑制和细胞吸引的行为，适当的 PEG 刷长促进了更高水平的钙沉积，并进一步促进了纤连蛋白的吸附，与原始钛合金表面相比。
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