Department of Health Statistics, School of Public Health, Shanxi Medical University, Taiyuan 030001, Shanxi Province, China; Department of Pharmacy and Office of Drug Clinical Trial Organization, Shanxi Cardiovascular Disease Hospital, Taiyuan 030001, Shanxi Province, China.
Department of Pharmacy and Office of Drug Clinical Trial Organization, Shanxi Cardiovascular Disease Hospital, Taiyuan 030001, Shanxi Province, China.
Clin Chim Acta. 2018 Oct;485:106-112. doi: 10.1016/j.cca.2018.06.036. Epub 2018 Jun 23.
Corin is a type II transmembrane serine protease that is highly expressed in the heart and plays a physiological role in the activation of natriuretic peptides. Corin is expressed primarily in myocytes, and it can enter the circulation. Circulating soluble corin has been found to be associated with various cardiovascular diseases, such as hypertension, heart failure, myocardial infarction, preeclampsia, and stroke. All these findings indicate that circulating soluble corin has the potential to be a sensitive and specific biomarker for risk prediction and prognostic assessment of cardiovascular diseases. However, there are certain challenges hindering the incorporation of circulating soluble corin into clinical practice. To provide new ideas based on the use of corin for risk prediction, prognostic assessment, and clinical treatment of cardiovascular diseases and to promote the implementation of corin as a routine laboratory index, we summarize the latest studies of the association between corin and cardiovascular diseases in recent years and offer some prospective proposals for future research on corin in this review.
卡里翁是一种 II 型跨膜丝氨酸蛋白酶，在心脏中高度表达，在利钠肽的激活中发挥生理作用。卡里翁主要在心肌细胞中表达，它可以进入循环系统。循环可溶性卡里翁已被发现与各种心血管疾病相关，如高血压、心力衰竭、心肌梗死、先兆子痫和中风。所有这些发现表明，循环可溶性卡里翁有可能成为心血管疾病风险预测和预后评估的敏感和特异性生物标志物。然而，有一些挑战阻碍了循环可溶性卡里翁纳入临床实践。为了基于卡里翁在心血管疾病的风险预测、预后评估和临床治疗中的应用提供新的思路，并促进将卡里翁作为常规实验室指标的实施，我们总结了近年来卡里翁与心血管疾病之间关联的最新研究，并为卡里翁的未来研究提出了一些前瞻性建议。
