Department of Obstetrics and Gynecology, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
Department of Biochemistry and Molecular Biology, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
Reprod Sci. 2024 Aug;31(8):2219-2227. doi: 10.1007/s43032-024-01531-w. Epub 2024 Apr 26.
Polycystic ovary syndrome (PCOS) is a prevalent endocrine disorder. Atrial natriuretic peptide (ANP) is a risk factor for PCOS. Corin protein has an essential role in ANP synthesis. This study aimed to evaluate corin as a sensitive biomarker for PCOS.
A case-control study was conducted with 70 PCOS patients and 70 healthy females. Plasma Corin levels were quantified using enzyme-linked immunosorbent assay.
The median plasma corin levels in PCOS patients and controls were 1785 and 822.5 pg/mL, respectively. Plasma corin levels were significantly elevated in PCOS patients than in the controls (p < 0.001). The optimal cut-off value was set at 1186 pg/mL. The sensitivity and specificity of Corin were 100% and 97.1%, respectively. Plasma corin levels were surrogate predictors for infertility in women with PCOS. It had an odds ratio of 5.9 (95% confidence interval: 1.1-32.7) (p = 0.04). Plasma corin levels were more highly detected in patients with PCOS than in the controls.
Plasma corin level has reasonable diagnostic interpretation for PCOS. Corin appears as a worthy distinct predictor of infertility in PCOS women. Therefore, Corin may be a substantial biomarker for PCOS.
多囊卵巢综合征（PCOS）是一种常见的内分泌疾病。心钠肽（ANP）是 PCOS 的一个危险因素。膜联蛋白 Corin 在 ANP 合成中起关键作用。本研究旨在评估 Corin 作为 PCOS 的敏感生物标志物。
采用病例对照研究，纳入 70 例 PCOS 患者和 70 名健康女性。采用酶联免疫吸附试验（ELISA）定量检测血浆 Corin 水平。
PCOS 患者和对照组的中位血浆 Corin 水平分别为 1785 和 822.5 pg/mL。PCOS 患者的血浆 Corin 水平明显高于对照组（p<0.001）。最佳截断值设定为 1186 pg/mL。Corin 的灵敏度和特异性分别为 100%和 97.1%。血浆 Corin 水平是 PCOS 患者不孕的替代预测指标。它的优势比为 5.9（95%置信区间：1.1-32.7）（p=0.04）。PCOS 患者的血浆 Corin 水平明显高于对照组。
血浆 Corin 水平对 PCOS 具有合理的诊断解释。Corin 似乎是 PCOS 患者不孕的一个有价值的独特预测指标。因此，Corin 可能是 PCOS 的一个重要生物标志物。
