Wu Qingyu
Department of Molecular Cardiology, Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA.
Front Biosci. 2007 May 1;12:4179-90. doi: 10.2741/2379.
Corin is a type II transmembrane serine protease expressed primarily in the heart. Functional studies have shown that corin converts pro-atrial natriuretic peptide (pro-ANP) to mature ANP, a cardiac hormone important in regulating salt-water balance and maintaining normal blood pressure. In corin-deficient mice, pro-ANP processing is abolished, demonstrating that corin is the physiological pro-ANP convertase. Corin-deficient mice develop hypertension that is exacerbated by a high-salt diet and during pregnancy, indicating the importance of this enzyme in controlling blood pressure. More recently, single nucleotide polymorphisms (SNPs) are found in the human corin gene, which are associated with an increased risk for hypertension and cardiac hypertrophy. This review describes the biology of corin and its potential role in cardiovascular disease.
Corin是一种主要在心脏中表达的II型跨膜丝氨酸蛋白酶。功能研究表明，Corin可将前心钠素（pro-ANP）转化为成熟的心钠素（ANP），ANP是一种在调节盐水平衡和维持正常血压方面起重要作用的心脏激素。在缺乏Corin的小鼠中，pro-ANP的加工过程被阻断，这表明Corin是生理性的pro-ANP转化酶。缺乏Corin的小鼠会出现高血压，高盐饮食和孕期会使这种高血压加剧，这表明该酶在控制血压方面的重要性。最近，在人类Corin基因中发现了单核苷酸多态性（SNP），这些多态性与高血压和心脏肥大风险增加有关。本文综述了Corin的生物学特性及其在心血管疾病中的潜在作用。
