Research Center for Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, PR China.
Research Center for Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, PR China.
Fitoterapia. 2018 Sep;129:162-166. doi: 10.1016/j.fitote.2018.06.020. Epub 2018 Jun 23.
Three new cembrane-type diterpenoids, deheiculatins M-O (1-3), together with five known analogues (4-8), were isolated from the twigs of Macaranga pustulata King ex Hook. The structures of new compounds 1-3 were elucidated by extensive spectroscopic analyses, modified Mosher's method, and the experimental and calculated electronic circular dichroism (ECD) experiments. All the isolates were evaluated for their cytotoxicity on three human cancer cell lines (CNE1, CNE2, and HCT 116), and all of them showed weak cytotoxicity (IC > 20 μM).
从大琴叶榕（Macaranga pustulata King ex Hook.）的嫩枝中分离得到了三个新的海松烷型二萜，即去海因酸 M-O（1-3），以及五个已知类似物（4-8）。通过广泛的光谱分析、改进的 Mosher 法以及实验和计算的电子圆二色性（ECD）实验确定了新化合物 1-3 的结构。对所有分离得到的化合物进行了三种人癌细胞系（CNE1、CNE2 和 HCT 116）的细胞毒性评价，结果显示它们均具有较弱的细胞毒性（IC > 20 μM）。
