Qi Wei-Yan, Shen Yu, Wu Yan, Leng Ying, Gao Kun, Yue Jian-Min
State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, People's Republic of China.
State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, People's Republic of China.
Phytochemistry. 2017 Apr;136:101-107. doi: 10.1016/j.phytochem.2017.01.009. Epub 2017 Jan 21.
Twelve cembranoids, deheiculatins A-L, were isolated from the leaves and twigs of Macaranga deheiculata. Their structures were elucidated on the basis of spectroscopic data. Five of these compounds displayed moderate inhibitory activity against human and/or mouse 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1). 20-Oxygenated cembranes are rare.
从毛桐的叶和嫩枝中分离出了12种西松烷类化合物，即去叶桐素A-L。根据光谱数据阐明了它们的结构。其中5种化合物对人源和/或小鼠源1型11β-羟基类固醇脱氢酶（11β-HSD1）表现出中等抑制活性。20-氧化西松烷类化合物很罕见。
