黄芩中的新穿心莲烷二萜类化合物。
Neoclerodane diterpenoids from Scutellaria barbata.
机构信息
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, Yunnan, P. R. China.
出版信息
Planta Med. 2011 Sep;77(13):1536-41. doi: 10.1055/s-0030-1270797. Epub 2011 Feb 25.
Eight new neoclerodane diterpenoids (1- 8), scutebatas H-O, together with eight known compounds, have been isolated from the whole plant of Scutellaria barbata D. Don. Their structures were elucidated on the basis of spectroscopic studies. In vitro cytotoxicity of selected compounds against cancer cell lines HL-60, SMMC-7721, A-549, MCF-7, and SW480 was evaluated. Compounds 5, 6, 7 showed moderate cytotoxicities against several human cancer cell lines, with IC50 values ranging from 12.6-31.4 µM. In addition, compound 1 showed selective cytotoxicity against MCF-7.
从 Scutellaria barbata D. Don 的全植物中分离得到了 8 个新的新克氏二萜类化合物（1-8），分别命名为 scutebatas H-O，同时还分离得到了 8 个已知化合物。基于光谱研究阐明了它们的结构。对选定的化合物对 HL-60、SMMC-7721、A-549、MCF-7 和 SW480 癌细胞系的体外细胞毒性进行了评估。化合物 5、6、7 对几种人癌细胞系表现出中等的细胞毒性，IC50 值范围为 12.6-31.4 μM。此外，化合物 1 对 MCF-7 表现出选择性细胞毒性。
Zotero 插件