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一种用于治疗雄激素性脱发和休止期脱发的专利草本提取物:一项安慰剂对照、单盲、临床仪器研究。

A proprietary herbal extract against hair loss in androgenetic alopecia and telogen effluvium: a placebo-controlled, single-blind, clinical-instrumental study.

作者信息

Pekmezci Erkin, Dündar Cihat, Türkoğlu Murat

机构信息

Department of Dermatology, Gözde Hospital, Malatya, Turkey.

R&D Center, Sancaktepe, Biota Laboratories, Istanbul, Turkey.

出版信息

Acta Dermatovenerol Alp Pannonica Adriat. 2018 Jun;27(2):51-57.

Abstract

INTRODUCTION

Currently there are only a limited number of drugs available for treatment of androgenetic alopecia and telogen effluvium. However, certain plants and their standardized extracts may provide some clinical benefits against hair loss. We formulated a herbal shampoo and a solution to evaluate their efficacy, safety, and synergy in hair loss.

METHODS

We conducted a randomized, placebo-controlled, single-blind, clinical and instrumental study for 6 months on 120 subjects with androgenetic alopecia and telogen effluvium, confirmed by pull test and phototricogram. Each subject was examined monthly. At the end of the study, a self-assessment test was carried out.

RESULTS

Herbal formulations were found to be more effective in preventing and reducing hair loss than placebo at every assessment point. Anagen/telogen ratios improved significantly in the study group. In addition, concomitant use of the shampoo and solution were found to be more effective than single product use.

CONCLUSION

We interpret this eutrophic effect for scalp hair as the final outcome of the entire content of our herbal formula, which has antiandrogenic, anti-inflammatory, antioxidative, angiogenic, and hair-stimulating features. In combination, these features help prevent hair from falling out and reducing hair loss.

摘要

引言

目前,可用于治疗雄激素性脱发和休止期脱发的药物数量有限。然而,某些植物及其标准化提取物可能对脱发具有一定的临床益处。我们配制了一种草本洗发水和一种溶液,以评估它们在脱发治疗中的疗效、安全性和协同作用。

方法

我们对120名经拔毛试验和光镜毛发图确诊为雄激素性脱发和休止期脱发的受试者进行了为期6个月的随机、安慰剂对照、单盲临床和仪器研究。每位受试者每月接受检查。研究结束时,进行了一项自我评估测试。

结果

在每个评估点,发现草本配方在预防和减少脱发方面比安慰剂更有效。研究组的生长期/休止期比率显著改善。此外,发现洗发水和溶液联合使用比单一产品使用更有效。

结论

我们将这种对头皮头发的营养丰富作用解释为我们草本配方全部成分的最终结果,该配方具有抗雄激素、抗炎、抗氧化、促血管生成和刺激头发生长的特性。这些特性共同作用有助于防止头发脱落并减少脱发。

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