Hill Aileen, Goetzenich Andreas, Marx Gernot, Stoppe Christian
Anasthesiol Intensivmed Notfallmed Schmerzther. 2018 Jun;53(6):466-479. doi: 10.1055/s-0043-121440. Epub 2018 Jun 26.
Cardiac surgery patients regularly experience a systemic inflammation response to the surgery and a postoperative stay in the intensive care unit. Nutritional support is one strategy to improve the outcome of cardiosurgical patients. A preoperatively diagnosed malnutrition contributes to a higher morbidity and mortality in this patient group. Preoperative fasting, glucose-free infusions during long and invasive operations and delayed postoperative nutrition therapy aggravate the nutrition situation. However, conclusive evidence for this population, consisting of well-conducted clinical trials is lacking.This article outlines the main causes for malnutrition in cardiosurgical patients and summarizes possibilities to identify patients at high nutritional risk, who are most likely to profit from aggressive nutritional therapy. Despite conspicuous knowledge and evidence gaps, a rational nutritional support therapy based on current recommendations of ASPEN, ESPEN and an international multidisciplinary consensus group is presented. The amount and kind of nutrition, as well as the best time to initiate nutrition support, ways to monitor nutrition therapy and the potential use of pharmaconutrition to modulate the inflammatory response to cardiopulmonary bypass are presented to benefit patients undergoing cardiac surgery.
心脏手术患者在术后入住重症监护病房期间,通常会经历全身性炎症反应。营养支持是改善心脏手术患者预后的一种策略。术前诊断出的营养不良会导致该患者群体更高的发病率和死亡率。术前禁食、长时间侵入性手术期间的无糖输液以及术后延迟营养治疗会加重营养状况。然而,针对这一人群的由精心设计的临床试验构成的确凿证据尚不存在。本文概述了心脏手术患者营养不良的主要原因,并总结了识别高营养风险患者的可能性,这些患者最有可能从积极的营养治疗中获益。尽管存在明显的知识和证据空白,但本文仍根据美国肠外肠内营养学会(ASPEN)、欧洲临床营养与代谢学会(ESPEN)以及一个国际多学科共识小组的当前建议,提出了一种合理的营养支持疗法。文中介绍了营养的量和种类、开始营养支持的最佳时间、监测营养治疗的方法以及使用营养药理学调节体外循环炎症反应的潜在用途,以造福接受心脏手术的患者。