Desnos J, Carbonnelle B, Kouyoumdjian S, Beucher A, Vacher S
Ann Otolaryngol Chir Cervicofac. 1985;102(5):351-6.
It is widely accepted that the cause of congenital deafness is genetic in one third of cases roughly, is due to acquired affections during pregnancy or delivery in another third and remains unknown in the last third. It is possible that the cytomegalovirus (CMV) plays an important role in the latter group. The CMV is thought to be involved in 10 to 30% of cases of auditory sequelae from fetal infection, either severe neonatal CMV-induced disease, which is rare, or the frequent subclinical infections affecting an average of 1% of newborn infants. The only certain way to determine the importance of the role of CMV in deafness of unknown etiology is large-scale neonatal biologic screening followed by long-term audiologic surveillance: currently available documented data suggest that this role is very important.
普遍认为,先天性耳聋的病因大致有三分之一是遗传因素,另外三分之一是由孕期或分娩期间获得性疾病引起的,而最后三分之一的病因仍不明确。巨细胞病毒(CMV)在后一组病因中可能起着重要作用。据认为,在胎儿感染导致的听觉后遗症病例中,10%至30%与CMV有关,这些病例要么是罕见的严重新生儿CMV诱发疾病,要么是平均影响1%新生儿的常见亚临床感染。确定CMV在病因不明的耳聋中所起作用的重要性的唯一确定方法是进行大规模新生儿生物学筛查,然后进行长期听力监测:目前可得的文献数据表明,这一作用非常重要。