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通过产时心动图联合胎儿心电图ST段分析(STAN)识别患有脐带血代谢性酸中毒的新生儿:新、旧国际妇产科联盟(FIGO)系统对产程图分类的比较

Identifying newborns with umbilical cord blood metabolic acidosis by intrapartum cardiotography combined with fetal ECG ST analysis (STAN): comparison of the new and old FIGO systems to classify cardiotocograms.

作者信息

Olofsson Per, Norén Håkan, Carlsson Ann, Rosén Karl G

机构信息

Institution of Clinical Sciences, Lund University, Malmö, Sweden.

Department of Obstetrics and Gynecology, Sahlgren's University Hospital, University of Gothenburg, Gothenburg, Sweden.

出版信息

J Matern Fetal Neonatal Med. 2020 Feb;33(3):404-409. doi: 10.1080/14767058.2018.1494148. Epub 2018 Oct 12.

DOI:10.1080/14767058.2018.1494148
PMID:29945485
Abstract

The intrapartum cardiotocography (CTG) classification system by FIGO in 2015 (FIGO2015) was introduced to simplify CTG interpretation, but it is not harmonized with the fetal ECG ST analysis (STAN) algorithm from 2007 (STAN2007), which is based on the FIGO CTG system from 1987. The study aimed to determine time courses and sensitivity between the systems in classifying CTG + ST events to indicate metabolic acidosis at birth. Forty-four cases with umbilical cord artery metabolic acidosis were retrieved from a European multicenter database. CTG patterns and timing of the first occurring significant ST events were evaluated in consensus by an expert panel and sensitivity statistics were performed. Wilcoxon's matched-pairs signed-ranks test and McNemar's test were used with a two-tailed  < .05 regarded significant. STAN2007 had a higher sensitivity (73 versus 43%,  = .0002) and alarmed for metabolic acidosis in mean 34 min earlier than the FIGO2015 system did ( = .002). In every fourth case, the time difference was ≥20 min. In this simulation study, surveillance with STAN2007 combined with fetal ECG ST analysis had a significantly higher sensitivity and would have alarmed for metabolic acidosis significantly earlier than the new FIGO system would have.

摘要

2015年国际妇产科联盟(FIGO)推出的产时胎心监护(CTG)分类系统(FIGO2015)旨在简化CTG解读,但它与2007年的胎儿心电图ST段分析(STAN)算法(STAN2007)不兼容,后者基于1987年的FIGO CTG系统。本研究旨在确定这两种系统在对CTG + ST事件进行分类以提示出生时代谢性酸中毒方面的时间进程和敏感性。从一个欧洲多中心数据库中检索出44例脐动脉代谢性酸中毒病例。由一个专家小组对CTG模式和首次出现显著ST事件的时间进行了一致性评估,并进行了敏感性统计。采用Wilcoxon配对符号秩检验和McNemar检验,双侧P < 0.05被视为具有显著性。STAN2007的敏感性更高(73%对43%,P = 0.0002),且比FIGO2015系统平均早34分钟发出代谢性酸中毒警报(P = 0.002)。在每四例病例中,时间差≥20分钟。在这项模拟研究中,使用STAN2007结合胎儿心电图ST段分析进行监测具有显著更高的敏感性,并且比新的FIGO系统更早发出代谢性酸中毒警报。

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