舒巴坦和氨苄西林在腹膜液中的穿透情况。
Penetration of sulbactam and ampicillin into peritoneal fluid.
作者信息
Wise R, Donovan I A, Andrews J M, Drumm J, Bennett S
出版信息
Antimicrob Agents Chemother. 1983 Aug;24(2):290-2. doi: 10.1128/AAC.24.2.290.
Abstract
Twenty-five patients undergoing elective intraabdominal surgery received either 1 or 2 g of ampicillin together with 1 g of sulbactam intravenously before surgery. The peritoneal levels of the agent were measured. Both compounds penetrated peritoneal fluid readily; the mean percentage of penetration by ampicillin was 92%; that of sulbactam was 96%. After 1 g of each agent, the peritoneal levels of sulbactam were 47% greater than those of ampicillin. Our results suggest that 2 g of ampicillin plus 1 g of sulbactam should provide peritoneal levels that would inhibit most susceptible beta-lactamase-producing pathogens encountered in intraabdominal sepsis.
摘要
25例接受择期腹部手术的患者在手术前静脉注射1克或2克氨苄西林以及1克舒巴坦。测定了药物在腹膜中的水平。两种化合物都能很容易地渗透到腹膜液中；氨苄西林的平均渗透百分比为92%；舒巴坦为96%。每种药物各使用1克后，舒巴坦在腹膜中的水平比氨苄西林高47%。我们的结果表明，2克氨苄西林加1克舒巴坦应能提供足以抑制腹腔感染中遇到的大多数易感产β-内酰胺酶病原体的腹膜水平。
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