Shen Xuxia, Jin Yan, Shen Lei, Sun Yihua, Chen Haiquan, Li Yuan
Department of Pathology, Fudan University Shanghai Cancer Center, 270 Dong-An Road, Shanghai, 200032, China.
Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.
Diagn Pathol. 2018 Jun 26;13(1):41. doi: 10.1186/s13000-018-0719-7.
Multilocular thymic cysts (MTCs) associated with thymomas or thymic carcinomas (TCs) are rare and may be misdiagnosed as other benign cystic lesions.
We retrospectively analysed 18 cases of thymomas or TCs associated with MTCs, which were retrieved from 309 consecutive patients with thymomas or TCs in the Chinese population, emphasizing clinicopathologic characteristics, immunophenotypes and the prognostic impact.
A total of 14 tumours were described as cystic or solid-cystic masses, and the other 4 tumours were described as solid masses. Histologically, 2 atypical type A, 2 type AB, 1 type B1, 8 type B2, 1 type B3, 1 microscopic thymoma (type A), 2 squamous cell carcinomas (SCCs) and 1 lymphoepithelioma-like carcinoma (LELC) were classified. Prominent multilocular cystic areas with chronic inflammation were observed. The follow-up ranged from 2 to 79 months. Sixteen patients survived without any evidence of recurrence after complete resection.
Our study suggests that thymomas or TCs associated with MTCs are rare in the Chinese population and have a better clinical behaviour than thymomas or TCs without MTCs. Our data also expand the histologic spectrum of thymomas or TCs accompanied by MTC. To our knowledge, this is the first report of atypical type A thymoma and LELC associated with MTCs.
与胸腺瘤或胸腺癌（TC）相关的多房性胸腺囊肿（MTC）较为罕见，可能被误诊为其他良性囊性病变。
我们回顾性分析了18例与MTC相关的胸腺瘤或TC，这些病例来自中国人群中连续309例胸腺瘤或TC患者，重点关注临床病理特征、免疫表型及预后影响。
共14个肿瘤被描述为囊性或实性-囊性肿块，另外4个肿瘤被描述为实性肿块。组织学上，分类为2例非典型A型、2例AB型、1例B1型、8例B2型、1例B3型、1例微小型胸腺瘤（A型）、2例鳞状细胞癌（SCC）和1例淋巴上皮瘤样癌（LELC）。观察到显著的多房性囊性区域伴有慢性炎症。随访时间为2至79个月。16例患者在完全切除后存活，无复发迹象。
我们的研究表明，与MTC相关的胸腺瘤或TC在中国人群中罕见，且临床行为比无MTC的胸腺瘤或TC更好。我们的数据还扩展了伴有MTC的胸腺瘤或TC的组织学谱。据我们所知，这是首例关于与MTC相关的非典型A型胸腺瘤和LELC的报告。
